Differential expression and emerging functions of non-coding RNAs in cold adaptation

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• 作者：Jacques J. Frigault ; Mathieu D. Morin ; Pier Jr Morin
• 关键词：Mammalian hibernation ; Insect cold hardiness ; Cold adaptation ; Non ; coding RNAs ; MicroRNAs ; Long non ; coding RNAs
• 刊名：Journal of Comparative Physiology B
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：187
• 期：1
• 页码：19-28
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Animal Physiology; Biomedicine, general; Human Physiology; Zoology; Biochemistry, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-136X
• 卷排序：187

文摘

Several species undergo substantial physiological and biochemical changes to confront the harsh conditions associated with winter. Small mammalian hibernators and cold-hardy insects are examples of natural models of cold adaptation that have been amply explored. While the molecular picture associated with cold adaptation has started to become clearer in recent years, notably through the use of high-throughput experimental approaches, the underlying cold-associated functions attributed to several non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), remain to be better characterized. Nevertheless, key pioneering work has provided clues on the likely relevance of these molecules in cold adaptation. With an emphasis on mammalian hibernation and insect cold hardiness, this work first reviews various molecular changes documented so far in these processes. The cascades leading to miRNA and lncRNA production as well as the mechanisms of action of these non-coding RNAs are subsequently described. Finally, we present examples of differentially expressed non-coding RNAs in models of cold adaptation and elaborate on the potential significance of this modulation with respect to low-temperature adaptation.