CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity
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- 作者：Tara Spence (1) (2)
Patrick Sin-Chan (1) (2)
Daniel Picard (1)
Mark Barszczyk (3)
Katharina Hoss (1)
Mei Lu (1)
Seung-Ki Kim (4)
Young-Shin Ra (5)
Hideo Nakamura (6)
Jason Fangusaro (7)
Eugene Hwang (8)
Erin Kiehna (9)
Helen Toledano (10)
Yin Wang (11)
Qing Shi (12)
Donna Johnston (13)
Jean Michaud (14)
Milena La Spina (15)
Anna Maria Buccoliero (16)
Dariusz Adamek (17)
Sandra Camelo-Piragua (18)
V. Peter Collins (19)
Chris Jones (20)
Nabil Kabbara (21)
Nawaf Jurdi (22)
Pascale Varlet (23)
Arie Perry (24)
David Scharnhorst (25)
Xing Fan (26)
Karin M. Muraszko (26)
Charles G. Eberhart (27)
Ho-Keung Ng (28)
Sridharan Gururangan (29)
Timothy Van Meter (30)
Marc Remke (31)
Lucie Lafay-Cousin (32)
Jennifer A. Chan (33)
Nongnuch Sirachainan (34)
Scott L. Pomeroy (35)
Steven C. Clifford (36)
Amar Gajjar (37)
Mary Shago (38)
William Halliday (3)
Michael D. Taylor (31)
Richard Grundy (39)
Ching C. Lau (40)
Joanna Phillips (24)
Eric Bouffet (1)
Peter B. Dirks (31)
Cynthia E. Hawkins (2) (3)
Annie Huang (1) (2) - 刊名：Acta Neuropathologica
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：128
- 期：2
- 页码：291-303
- 全文大小：1,942 KB
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Patrick Sin-Chan (1) (2)
Daniel Picard (1)
Mark Barszczyk (3)
Katharina Hoss (1)
Mei Lu (1)
Seung-Ki Kim (4)
Young-Shin Ra (5)
Hideo Nakamura (6)
Jason Fangusaro (7)
Eugene Hwang (8)
Erin Kiehna (9)
Helen Toledano (10)
Yin Wang (11)
Qing Shi (12)
Donna Johnston (13)
Jean Michaud (14)
Milena La Spina (15)
Anna Maria Buccoliero (16)
Dariusz Adamek (17)
Sandra Camelo-Piragua (18)
V. Peter Collins (19)
Chris Jones (20)
Nabil Kabbara (21)
Nawaf Jurdi (22)
Pascale Varlet (23)
Arie Perry (24)
David Scharnhorst (25)
Xing Fan (26)
Karin M. Muraszko (26)
Charles G. Eberhart (27)
Ho-Keung Ng (28)
Sridharan Gururangan (29)
Timothy Van Meter (30)
Marc Remke (31)
Lucie Lafay-Cousin (32)
Jennifer A. Chan (33)
Nongnuch Sirachainan (34)
Scott L. Pomeroy (35)
Steven C. Clifford (36)
Amar Gajjar (37)
Mary Shago (38)
William Halliday (3)
Michael D. Taylor (31)
Richard Grundy (39)
Ching C. Lau (40)
Joanna Phillips (24)
Eric Bouffet (1)
Peter B. Dirks (31)
Cynthia E. Hawkins (2) (3)
Annie Huang (1) (2)
1. Division of Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, Arthur and Sonia Labatt Brain Tumor Research Centre, Peter Gilgan CRL,686 Bay Street, 17th Floor, 179712, Toronto, ON, M5G0A4, Canada
2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
3. Department of Pathology, The Hospital for Sick Children, Toronto, ON, Canada
4. Department of Neurosurgery, Seoul National University Children鈥檚 Hospital, Seoul, South Korea
5. Department of Neurosurgery, Asan Medical Center, Seoul, South Korea
6. Department of Neurosurgery, Kumamoto University, Kumamoto, Japan
7. Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Children鈥檚 Memorial Hospital, Chicago, IL, USA
8. Center for Cancer and Blood Disorders, Children鈥檚 National Medical Center, Washington, DC, USA
9. Department of Neurosurgery, Children鈥檚 Hospital of Los Angeles, Los Angeles, CA, USA
10. Oncology Department, Schneider Hospital, Petach Tikva, Israel
11. Department of Neuropathology Huashan Hospital, Fudan University, Shanghai, China
12. Department of Pathology, Shanghai Children鈥檚 Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China
13. Department of Pediatrics, Children鈥檚 Hospital of Eastern Ontario, Ottawa, ON, Canada
14. Department of Pathology and Laboratory Medicine, Children鈥檚 Hospital of Eastern Ontario, Ottawa, ON, Canada
15. Paediatric Haematology and Oncology Division, University of Catania, Sicily, Italy
16. Pathology Unit Meyer Children鈥檚 Hospital, Florence, Italy
17. Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland
18. Department of Pathology, University of Michigan, Ann Arbor, MI, USA
19. Department of Pathology, University of Cambridge, Cambridge, UK
20. Department of Paediatric Molecular Pathology, Institute of Cancer Research, Sutton, UK
21. Division of Pediatric Hematology Oncology, Rafic Hariri University Hospital, Beirut, Lebanon
22. Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
23. Medical and Department of Neuropathology, Sainte-Anne Hospital, University Paris V Descartes, Paris, France
24. Department of Pathology and Laboratory Medicine, University of California, San Francisco, CA, USA
25. Department of Pathology, Children鈥檚 Hospital Central California, Madera, CA, USA
26. Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA
27. Division of Pathology, John Hopkins University School of Medicine, Baltimore, MD, USA
28. Department of Anatomical and Cellular Physiology, Chinese University of Hong Kong, Hong Kong, China
29. Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
30. Department of Pediatrics, Virginia Commonwealth University, Richmond, VA, USA
31. Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
32. Department of Pediatric Oncology, Alberta Children鈥檚 Hospital, Calgary, AB, Canada
33. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada
34. Departments of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
35. Department of Neurology, Children鈥檚 Hospital Boston, Boston, MA, USA
36. Northern Institute for Cancer Research, Newcastle University, Newcastle Upon Tyne, UK
37. Neuro-oncology Division, St Jude Children鈥檚 Research Hospital, Memphis, TN, USA
38. Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada
39. Children鈥檚 Brain Tumor Research Centre, Queen鈥檚 Medical Centre University of Nottingham, Nottingham, UK
40. Texas Children鈥檚 Cancer Center, Baylor College of Medicine, Houston, TX, USA - ISSN：1432-0533
文摘
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specificity of C19MC and LIN28, and the clinical and biological spectra of C19MC amplified and/or LIN28+ CNS-PNETs. We interrogated 450 pediatric brain tumors using FISH and IHC analyses and demonstrate that C19MC alteration is restricted to a sub-group of CNS-PNETs with high LIN28 expression; however, LIN28 immunopositivity was not exclusive to CNS-PNETs but was also detected in a proportion of other malignant pediatric brain tumors including rhabdoid brain tumors and malignant gliomas. C19MC amplified/LIN28+ group 1 CNS-PNETs arose predominantly in children PI3K/mTOR axis and DNMT3B as promising therapeutics for this distinct histogenetic entity.