Supramolecular encapsulation of doxorubicin with β-cyclodextrin dendrimer: in vitro evaluation of controlled release and cytotoxicity

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• 作者：Toomari Yousef ; Namazi Hassan
• 关键词：Dendrimer ; β ; Cyclodextrin ; Nanocarrier ; Drug delivery ; Supramolecular inclusion complex
• 刊名：Journal of Inclusion Phenomena and Macrocyclic Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：87
• 期：1-2
• 页码：105-115
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Organic Chemistry; Food Science; Crystallography and Scattering Methods;
• 出版者：Springer Netherlands
• ISSN：1573-1111
• 卷排序：87

文摘

In this study, the formation of supramolecular inclusion complex of doxorubicin (DOX), a high loading and pH-dependent delivery of DOX on β-CD dendrimer was studied. β-cyclodextrin (β-CD) dendrimer having β-CD in both periphery and core was prepared with entrapment efficiency using click reaction. The encapsulation property of the β-CD-dendrimer was investigated by DOX as model drug. The chemical construction of β-CD-dendrimer was described by 1H NMR, 13C NMR and FTIR and its inclusion complex construction was studied by FTIR, DSC, SEM, and DLS techniques. It was confirmed that β-CD dendrimer able to encapsulate DOX in solution; as a result, the designed complex revealed pH-dependent sustained release of DOX, in vitro. Also, the in vitro outcomes on T47D cells displayed that complexation of DOX with β-CD dendrimer involved an improvement of in vitro cytotoxicity and anticancer activity and this data appeared to be as a result of the developed solubility of the DOX.