Synthesis and bioactivity of a novel bismuthoxide Schiff-base complex derived from Salen-like ligand and bismuth(III) nitrate
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- 作者：Chuanhua Li ; Jianhong Jiang ; Xu Li…
- 刊名：Chemical Research in Chinese Universities
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：32
- 期：2
- 页码：207-211
- 全文大小：377 KB
- 刊物主题：Chemistry/Food Science, general; Analytical Chemistry; Inorganic Chemistry; Organic Chemistry; Physical Chemistry;
- 出版者：Springer Berlin Heidelberg
- ISSN：2210-3171
- 卷排序：32
文摘
In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8(vanen)3(NO3)2(CH3OH)2(H2O)·3NO3·5.5H2O](abbreviated as Bivanen) was synthesized with Salen-like ligand[H2vanen=N,N’-ethylene bis(3-methoxy-salicylideneimine)] and bismuth(III) nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaccharomyces pombe (S. pombe) were studied using biological microcalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 °C. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant(k), inhibition ratio(I) and half inhibition concentration(IC50) were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.KeywordsBismuth Schiff-base complexMicrocalorimetriyThermokinetic propertySchizosaccharomyces pombe(S. Pombe)