Constituents from the leaves of Clausena lansium and their anti-inflammatory activity
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- 作者：De-Yang Shen ; Ping-Chung Kuo ; Shiow-Chyn Huang…
- 关键词：Clausenalansamide ; Electronic circular dichroism ; Single ; crystal X ; ray diffraction analysis ; Anti ; inflammatory ; Superoxide anion generation
- 刊名：Journal of Natural Medicines
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：71
- 期：1
- 页码：96-104
- 全文大小：
- 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
- 出版者：Springer Japan
- ISSN：1861-0293
- 卷排序：71
文摘
Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.
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