Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production
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- 作者：Jing Zhang ; Cong Quan ; Cheng Wang ; Hui Wu ; Zhimin Li ; Qin Ye
- 关键词：Escherichia coli ; Glutathione ; Systematic manipulation ; Bifunctional glutathione synthetase ; Fed ; batch fermentation
- 刊名：Microbial Cell Factories
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：15
- 期：1
- 全文大小：1,250 KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Biotechnology
Applied Microbiology
Environmental Engineering/Biotechnology - 出版者：BioMed Central
- ISSN：1475-2859
文摘
Background l-glutathione (GSH) is a non-protein thiol compound with important biological properties and is widely used in pharmaceutical, food, cosmetic and health products. The cellular GSH is determined by the activity and characteristic of GSH-synthesizing enzymes, energy and precursor supply, and degradation of formed GSH.