A green one-pot three-component cascade reaction: the synthesis of 2-amino-5,8-dihydro-3H-pyrido[2,3-D]pyrimidin-4-ones in aqueous medium
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- 作者：Ahmad Shaabani ; Heshmatollah Sepahvand ; Mahmoud Borjian Boroujeni…
- 关键词：Green synthesis ; Three ; component reaction ; Dihydropyridopyrimidine ; Acetophenone ; 2 ; 6 ; Diaminopyrimidin ; 4(3H) ; one ; MCR
- 刊名：Molecular Diversity
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：21
- 期：1
- 页码：147-153
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Biochemistry, general; Organic Chemistry; Polymer Sciences; Pharmacy;
- 出版者：Springer International Publishing
- ISSN：1573-501X
- 卷排序：21
文摘
A one-pot three-component cascade reaction for the green synthesis of a new class of 2-amino-5,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-ones was developed from the condensation of aromatic aldehydes with 2,6-diaminopyrimidin-4(3H)-one and acetophenone derivatives or various cyclic ketones in the presence of a catalytic amount of sodium carbonate in a mixture of water and ethanol at 60 \({^{\circ }}\hbox {C}\). This reaction led to the construction of two carbon–carbon bonds and one carbon–nitrogen bond in a single synthetic step.