Effective computational modeling of erythrocyte electro-deformation

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• 作者：Nicola A. Nodargi ; Paolo Bisegna ; Federica Caselli
• 关键词：Electro ; deformation ; Maxwell stress tensor ; Erythrocyte mechanics ; Homogenization ; Finite elements ; Corotational formulation
• 刊名：Meccanica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：52
• 期：3
• 页码：613-631
• 全文大小：
• 刊物类别：Physics and Astronomy
• 刊物主题：Classical Mechanics; Civil Engineering; Automotive Engineering; Mechanical Engineering;
• 出版者：Springer Netherlands
• ISSN：1572-9648
• 卷排序：52

文摘

Due to its crucial role in pathophysiology, erythrocyte deformability represents a subject of intense experimental and modeling research. Here a computational approach to electro-deformation for erythrocyte mechanical characterization is presented. Strong points of the proposed strategy are: (1) an accurate computation of the mechanical actions induced on the cell by the electric field, (2) a microstructurally-based continuum model of the erythrocyte mechanical behavior, (3) an original rotation-free shell finite element, especially suited to the application in hand. As proved by the numerical results, the developed tool is effective and sound, and can foster the role of electro-deformation in single-cell mechanical phenotyping.