Aerosolization, Drug Permeation and Cellular Interaction of Dry Powder Pulmonary Formulations of Corticosteroids with Hydroxypropyl-β-Cyclodextrin as a Solubilizer
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- 作者：Ville Vartiainen ; Luis M. Bimbo ; Jouni Hirvonen…
- 关键词：KEY WORDScoating ; cyclodextrin ; permeation ; poorly soluble drug ; pulmonary
- 刊名：Pharmaceutical Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：34
- 期：1
- 页码：25-35
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
- 出版者：Springer US
- ISSN：1573-904X
- 卷排序：34
文摘
PurposeThe purpose of this study was to assess the feasibility of hydroxypropyl-β-cyclodextrin as a solubilizer for the corticosteroids prednisolone and fludrocortisone acetate in dry powder inhalation formulations.