Preclinical Evaluation of an Anti-Nectin-4 ImmunoPET Reagent in Tumor-Bearing Mice and Biodistribution Studies in Cynomolgus Monkeys
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- 作者：Dean O. Campbell ; Akihiro Noda ; Alla Verlinsky…
- 关键词：Key wordsImmunoPET ; Nectin ; 4 ; Liver imaging ; Zr ; 89 PET
- 刊名：Molecular Imaging and Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：18
- 期：5
- 页码：768-775
- 全文大小：3,036 KB
- 刊物主题：Imaging / Radiology;
- 出版者：Springer US
- ISSN：1860-2002
- 卷排序：18
文摘
PurposeNectin-4 is selectively overexpressed in a variety of cancers and is currently under clinical investigation as a therapeutic target. A monoclonal antibody against nectin-4 (AGS-22M6) was evaluated as an Immuno-positron emission tomography (ImmunoPET) reagent. Its ability to assay nectin-4 expression as well as detect nectin-4 positive tumors in the liver and bone was evaluated using mouse models.