The effect of CYP1A1 and CYP1A2 polymorphisms on gastric cancer risk among different ethnicities: a systematic review and meta-analysis

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• 作者：Huiping Xue (1) (2)
  Yan Lu (3)
  Zeyun Xue (4)
  Bing Lin (5)
  Jinxian Chen (6)
  Feng Tang (7)
  Gang Huang (3) (8) (9)
  
• 关键词：Cytochrome P450s (CYPs) ; Gene ; Polymorphism ; Association ; Gastric cancer
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：35
• 期：5
• 页码：4741-4756
• 全文大小：
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• 作者单位：Huiping Xue (1) (2)
  Yan Lu (3)
  Zeyun Xue (4)
  Bing Lin (5)
  Jinxian Chen (6)
  Feng Tang (7)
  Gang Huang (3) (8) (9)
  
  1. Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
  2. Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiaotong University), Shanghai, People’s Republic of China
  3. Department of Medicine, International Peace Hospital for the Protection of Mother and Child Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
  4. Shanghai High School, Shanghai, People’s Republic of China
  5. Division of Nutrition, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, People’s Republic of China
  6. Department of General Surgery, Renji Hospital, Shanghai, People’s Republic of China
  7. Division of Pathology, Huashan Hospital, School of Medicine, Fudan University School of Medicine, Shanghai, People’s Republic of China
  8. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People’s Republic of China
  9. Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200025, People’s Republic of China
  
• ISSN：1423-0380

文摘

Potential Cytochrome P450s (CYPs) 1A1 MspI, 1A1 Ile462Val, 1A2*1?F, and/or 1A2*1C polymorphisms have been implicated in gastric cancer risk among different ethnicities. We aimed to explore the effect of CYP 1A1 MspI, 1A1 Ile462Val, 1A2*1?F, and/or 1A2*1C polymorphisms on the susceptibility to gastric cancer among different ethnicities through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. A number of 11 studies were ultimately eligible for the meta-analysis of CYP1A1 MspI polymorphism, eight studies for the meta-analysis of 1A1 Ile462Val polymorphism, and two studies for the meta-analysis of 1A2*1?F polymorphism. None of genetic model was evidently suggested, and thus all the genetic models were presented. Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated. In our meta-analysis, significant results could be found in mutational heterozygous CT genotype, compared with wild TT genotype, among large sample size subgroup for CYP1A1 MspI polymorphism. Regarding CYP1A1 Ile462Val polymorphism, no statistically significant results could be found. For CYP1A2*1?F polymorphism, mutational heterozygous AC genotype, compared with wild-type AA, has deleterious effects, whereas mutational homozygous CC genotype, compared with mutational heterozygous type AC, has protective effects but lacks statistically significant difference despite its a proximity to 0.05. Combined mutational homozygous CC genotype and wild-type homozygous AA, compared with mutational heterozygous AC genotype, has protective effects. Our meta-analysis suggests no associations between CYP1A1 Ile462Val polymorphism and gastric cancer, but possible associations between CYP1A1 MspI and CYP1A2*1?F polymorphisms and gastric cancer, which needs to be further reinforced or refuted among different ethnicities in well-designed large-scale high-quality studies.