文摘
This study was conducted to investigate the possible correlation of chronic renal dysfunction and albuminuria with the severity of coronary artery lesions in patients with coronary artery disease (CAD). Two-hundred and ninety-nine patients who had undergone coronary angiography for suspected CAD were stratified into three groups according to the glomerular filtration rate (GFR): group I included 144 patients with normal renal function GFR?>90?ml/(min?×?1.73?m2), group II included 97 patients with mild renal impairment GFR 60-9?ml/(min?×?1.73?m2), and group III included 58 patients with moderate renal impairment GFR?<60?ml/(min?×?1.73?m2). Patients were then stratified into two groups according to the albuminuria level (0; minimal, 1+, 2+, 3+): the albuminuria negative group (negative?=?0) included 171 patients and the albuminuria positive group (positive?=?minimal, 1+, 2+, 3+) included 128 patients. Clinical features and coronary lesion characteristics were compared among these groups. Patients with more severe renal dysfunction and positive albuminuria had a higher incidence of CAD (66.7 vs. 70.1 vs. 72.4?%, p?=?0.025 and 64.2 vs. 75.0?%, p?=?0.032), more multi-vessel disease (31.2 vs. 41.2 vs. 53.4?%, p?=?0.004 and 33.3 vs. 46.1?%, p?=?0.015), more left anterior descending branch lesions (50.7 vs. 56.7 vs. 60.3?%, p?=?0.012 and 49.1 vs. 61.7?%, p?=?0.009), and a higher Gensini score (42.3?±?14.7 vs. 46.1?±?19.9 vs. 52.8?±?21.2, p?=?0.026 and 44.0?±?16.0 vs. 50.5?±?20.2, p?=?0.017). In conclusion, chronic renal dysfunction and albuminuria may be important factors determining the occurrence and the severity of CAD. Albuminuria was an especially significant indicator at the early stage of renal dysfunction.