Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury
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- 作者：Chengrui An ; Xiaoyan Jiang ; Hongjian Pu ; Dandan Hong…
- 关键词：Traumatic brain injury ; Long ; term spatial learning ; memory deficits ; White matter injury ; Hippocampus
- 刊名：Translational Stroke Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：7
- 期：6
- 页码：512-520
- 全文大小：1,695 KB
- 刊物主题：Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery;
- 出版者：Springer US
- ISSN：1868-601X
- 卷排序：7
文摘
Traumatic brain injury (TBI) is a major cause of death and disability in young adults. Long-term mental disability often occurs in patients suffering moderate and severe TBI while not as frequent in the victims of mild TBI. To explore the potential mechanism underlying this severity-dependent cognitive deficit, we subjected C57/BL6 mice to different severities of controlled cortical impact (CCI) and assessed their learning-memory functions. The mice subjected to moderate and severe TBI exhibited significantly impaired long-term spatial learning-memory ability, which was accompanied by marked white matter injury and hippocampus damage. In contrast, long-term learning-memory deficits or structural abnormalities within the hippocampus or white matter were not significant in the case of mild TBI. According to a correlation analysis, the hippocampus or white matter injury severity was more relevant to Morris water maze outcome than tissue volume. This study revealed that long-term spatial learning-memory deficits are dependent on the severity of destruction in the white matter and hippocampus. Therapeutic strategies targeting both the white matter and hippocampus may be needed to improve the neurological functions in TBI victims.