Extracellular actin in health and disease
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- 作者：N. P. Sudakov ; I. V. Klimenkov ; V. A. Byvaltsev ; S. B. Nikiforov…
- 关键词：actin ; danger associated molecular patterns ; gelsolin ; Gc ; globulin ; anti ; actin antibodies ; pathologies ; biomarkers
- 刊名：Biochemistry (Moscow)
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：82
- 期：1
- 页码：1-12
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biochemistry, general; Bioorganic Chemistry; Microbiology; Biomedicine, general;
- 出版者：Pleiades Publishing
- ISSN：1608-3040
- 卷排序：82
文摘
This review considers the functions of extracellular actin–cell surface bound, associated with extracellular matrix, or freely circulating. The role of this protein in different pathological processes is analyzed: its toxic effects and involvement in autoimmune diseases as an autoantigen. The extracellular actin clearance system and its role in protection against the negative effects of actin are characterized. Levels of free-circulating actin, anti-actin immunoglobulins, and components of the actin clearance system as prognostic biomarkers for different diseases are reviewed. Experimental approaches to protection against excessive amounts of free-circulating F-actin are discussed.