Lack of Association Between TESPA1 Gene Polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and Ankylosing Spondylitis in a Chinese Population
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- 作者：Si Liu (1)
Li Liu (1)
Shanshan Wu (1)
Ting Yang (1)
Faming Pan (1)
Laura Laslett (3)
Guo Xia (1)
Yanting Hu (1)
Dazhi Fan (1)
Ning Ding (1)
Shengqian Xu (2)
Guoqi Cai (1)
Li Wang (1)
Lihong Xin (1) - 关键词：TESPA1 gene ; ankylosing spondylitis ; single ; nucleotide polymorphisms ; case ; control studies
- 刊名：Inflammation
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：37
- 期：6
- 页码：2040-2046
- 全文大小：155 KB
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Li Liu (1)
Shanshan Wu (1)
Ting Yang (1)
Faming Pan (1)
Laura Laslett (3)
Guo Xia (1)
Yanting Hu (1)
Dazhi Fan (1)
Ning Ding (1)
Shengqian Xu (2)
Guoqi Cai (1)
Li Wang (1)
Lihong Xin (1)
1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China
3. Menzies Research Institute Tasmania—University of Tasmania, Hobart, TAS, 7000, Australia
2. Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China - ISSN：1573-2576
文摘
We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497, rs4758994, and rs997173) in the TESPA1 gene. We found no evidence of association between these SNPs and AS susceptibility, and between their haplotypes and the disease. But, patients with rs1801876 GA, GG, and AA genotypes had significantly different Bath Ankylosing Spondylitis Functional Index (BASFI) scores (p--.023). There were significantly different visual analogue scale (VAS) night pain assessment scores (p--.040) and BASFI scores (p--.023) among different genotypes at rs2171497 locus. There were also significantly different chest expansion scores (p--.042) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (p--.014) among different genotypes at rs997173 locus. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, clinical characteristics of these three loci showed association between different genotype groups. These findings indicated that the TESPA1 gene is not involved in AS genetic predisposition in the Han Chinese population; however, it may play an important role in the clinical characteristics of AS.