Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine

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• 作者：Mikkel Staberg ; Signe Regner Michaelsen ; Rikke Darling Rasmussen…
• 关键词：Glioblastoma ; Epigenetics ; Trichostatin A ; HDACi ; Lomustine ; Sensitization
• 刊名：Cellular Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：1
• 页码：21-32
• 全文大小：
• 刊物主题：Cancer Research; Biomedicine, general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436
• 卷排序：40

文摘

PurposeGlioblastoma (GBM) ranks among the deadliest solid cancers worldwide and its prognosis has remained dismal, despite the use of aggressive chemo-irradiation treatment regimens. Limited drug delivery into the brain parenchyma and frequent resistance to currently available therapies are problems that call for a prompt development of novel therapeutic strategies. While only displaying modest efficacies as mono-therapy in pre-clinical settings, histone deacetylase inhibitors (HDACi) have shown promising sensitizing effects to a number of cytotoxic agents. Here, we sought to investigate the sensitizing effect of the HDACi trichostatin A (TSA) to the alkylating agent lomustine (CCNU), which is used in the clinic for the treatment of GBM.