Vitamin D deficiency aggravates diabetes-induced muscle wasting in female mice

详细信息    查看全文

• 作者：Yukinori Tamura ; Haruko Fujito ; Naoyuki Kawao ; Hiroshi Kaji
• 关键词：Vitamin D ; Diabetes ; Muscle wasting ; Myoblast
• 刊名：Diabetology International
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：8
• 期：1
• 页码：52-58
• 全文大小：
• 刊物主题：Diabetes; Metabolic Diseases; Endocrinology;
• 出版者：Springer Japan
• ISSN：2190-1686
• 卷排序：8

文摘

We recently reported that vitamin D deficiency aggravates diabetic bone loss in mice. Although vitamin D affects both muscle and bone, the role of the vitamin D state in diabetic muscle loss and muscle-bone relationships remains unclear. In the present study, we examined the effects of vitamin D deficiency on muscle mass, muscle differentiation and muscle-derived humoral factors linking muscle to bone in diabetic female mice. Diabetes was induced in mice by streptozotocin (STZ) injection after feeding with a normal or vitamin D-deficient diet for 6 weeks. Quantitative computed tomography analysis showed that tibial muscle mass was significantly decreased in diabetic mice compared with control mice 4 weeks after induction of diabetes. Vitamin D deficiency accelerated muscle loss in diabetic mice. Vitamin D deficiency augmented the decreases in Pax7 mRNA levels and the increases in muscle RING-Finger Protein-1 and atrogin-1 mRNA levels induced by diabetes in the gastrocnemius muscle of mice. Moreover, vitamin D deficiency decreased the mRNA levels of insulin-like growth factor-1, fibroblast growth factor-2 and osteoglycin in muscle of diabetic mice. In conclusion, we demonstrated that vitamin D deficiency aggravates muscle loss induced by diabetes in female mice. Vitamin D may exert significant effects on the maintenance of the musculoskeletal system partly through the muscle-bone relationships in diabetic state.