P Selectins and immunological profiles in HCV and Schistosoma mansoni induced chronic liver disease

详细信息    查看全文

• 作者：Mahmoud M Kamel (1)
  Shawky A Fouad (2)
  Maha MA Basyoni (3)
  
  1. Department of Clinical Pathology ; National Cancer Institute Cairo University ; Cairo ; Egypt
  2. Department of Internal Medicine ; Faculty of Medicine ; Cairo University ; Cairo ; Egypt
  3. Department of Medical Parasitology ; Faculty of Medicine ; Cairo University ; Cairo ; Egypt
  
• 关键词：HCV ; Schistosomiasis mansoni ; Activated platelets ; CD62 ; Lymphocyte activation
• 刊名：BMC Gastroenterology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：370 KB
• 参考文献：1. Leslie, M (2010) Cell biology: Beyond clotting: The powers of platelets. Science 328: pp. 562-564 26/science.328.5978.562" target="_blank" title="It opens in new window">CrossRef
  2. Morrell, CN, Aggrey, AA, Chapman, LM, Modjeski, KL (2014) Emerging roles for platelets as immune and inflammatory cells. Blood 123: pp. 2759-2767 2/blood-2013-11-462432" target="_blank" title="It opens in new window">CrossRef
  3. Bonnard, P, Vitte, RL, Barbare, JC, Denis, J, Stepani, P, Di Martino, V, Coutarel, P, Eug猫ne, C, Van Batten, C, Cadranel, JF (1999) Is bleeding time measurement useful for choosing the liver biopsy route? The results of a pragmatic, prospective multicentric study in 219 patients. J Clin Gastroenterol 29: pp. 347-9 2000-00013" target="_blank" title="It opens in new window">CrossRef
  4. Soares, S, Rodrigues J煤nior, V, Silva, DT, Moraes-Souza, H (2007) Participation of platelets in the process of fibrosis in patients with mansonic schistosomiasis. Rev Soc Bras Med Trop 40: pp. 321-325 22007000300014" target="_blank" title="It opens in new window">CrossRef
  5. Nowatari, T, Murata, S, Fukunaga, K, Ohkohchi, N (2014) Role of platelets in chronic liver disease and acute liver injury. Hepatol Res 44: pp. 165-172 2205" target="_blank" title="It opens in new window">CrossRef
  6. Gudbrandsdottir, S, Hasselbalch, HC, Nielsen, CH (2013) Activated platelets enhance IL-10 secretion and reduce TNF-伪 secretion by monocytes. J Immunol 191: pp. 4059-4067 201103" target="_blank" title="It opens in new window">CrossRef
  7. Elias, JA, Zitnik, RJ (1992) Cytokine-cytokine interactions in the context of cytokine networking. Am J Respir Cell Mol Biol 7: pp. 365-367 CrossRef
  8. Chiaramonte, MG, Cheever, AW, Malley, JD, Donaldson, DD, Wynn, TA (2001) Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34: pp. 273-282 2001.26376" target="_blank" title="It opens in new window">CrossRef
  9. Catherine, O, Jayat-Vignoles, C, Magali, D, Jean, F (2011) Both CD62 and CD162 Antibodies Prevent Formation of CD36-Dependent Platelets, Rosettes, and Artefactual Pseudoexpression of Platelet Markers on White Blood Cells: A Study with Image Stream. Cytometry A 79A: pp. 477-484 2/cyto.a.21050" target="_blank" title="It opens in new window">CrossRef
  10. Wynn, TA, Hesse, M, Sandler, NG, Kaviratne, M, Hoffmann, KF, Chiaramonte, MG, Reiman, R, Cheever, AW, Sypek, JP, Mentink-Kane, MM (2004) P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor. Hepatology 39: pp. 676-87 2/hep.20102" target="_blank" title="It opens in new window">CrossRef
  11. Austrup, F, Vestweber, D, Borges, E, L枚hning, M, Br盲uer, R, Herz, U, Renz, H, Hallmann, R, Scheffold, A, Radbruch, A, Hamann, A (1997) P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 385: pp. 81-83 CrossRef
  12. Balakrishna, J, Venkateswarlu, S, Kusuma, B, Hussain Saheb, S (2013) Comparison of modified 1% potassium hydroxide formol-ether concentration technique with direct wet mount preparation and standard formol-ether concentration technique for detection of parasites in stool. J Pharm Sci 5: pp. 147-149
  13. Engvall, E, Perlman, P (1971) ELISA quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen coated tubes. J Immunol 109: pp. 129-135
  14. Guesdon, JL, Ternynck, T, Avrameas, S (1979) The use of avidin biotin interaction in 24 immune-enzymatic techniques. J Histochem Cytochem 27: pp. 1131-1139 27.8.90074" target="_blank" title="It opens in new window">CrossRef
  15. Kishirnoto, T, Goyert, S, Kikutani, H, Mason, D, Miyasaka, M, Moretto, L, Ohno, T, Okurnura, K, Shaw, S, Springer, TA, Sugarnura, K, Sugawara, H, Borne AEG Kr, V d, Zola, H (1997) Update of CD antigens. J Immunol 158: pp. 3035-3036
  16. Panasiuk, A, Prokopowicz, D, Zak, J, Matowicka-Karna, J, Osada, J, Wysocka, J (2001) Activation of blood platelets in chronic hepatitis and liver cirrhosis p-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and p1q2鈥檈let factor-4. Hepatogastroenterology 48: pp. 818-822
  17. Grakoui, A, Shoukry, NH, Woollard, DJ, Han, JH, Hanson, HL (2003) HCV persistence and immune evasion in the absence of memory T cell help. Science 302: pp. 659-662 26/science.1088774" target="_blank" title="It opens in new window">CrossRef
  18. Schirren, CA, Jung, MC, Worzfeld, T, Mamin, M, Baretton, G, Gerlach, JT (2001) Hepatitis C virus-specific CD4+ T cell response after liver transplantation occurs early, is multispecific, compartmentalizes to the liver and does not correlate with recurrent disease. J Infect Dis 183: pp. 1187-1194 2" target="_blank" title="It opens in new window">CrossRef
  19. Fernandez-Ponce, C, Dominguez-Villar, M, Aguado, E, Garcia-Cozar, F (2014) CD4+ Primary T Cells Expressing HCV-Core Protein Upregulate Foxp3 and IL-10, Suppressing CD4 and CD8 T Cells. PLoS One.
  20. Davies, SJ, Grogan, JL, Blank, RB, Lim, KC, Locksley, RM, McKerrow, JH (2001) Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science 294: pp. 1358-1361 26/science.1064462" target="_blank" title="It opens in new window">CrossRef
  21. Kullberg, MC, Pearce, EJ, Hieny, SE, Sher, A, Berzofsky, JA (1992) Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen. J Immunol 148: pp. 3264
  22. Manfras, BJ, Weidenbach, H, Beckh, KH, Kern, P, Moller, P, Adler, G (2004) Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-alpha therapy. J Clin Immunol 24: pp. 258-271 23/B:JOCI.0000025447.23473.ab" target="_blank" title="It opens in new window">CrossRef
  23. Li, Y, Zeng, Q, Ellis, MK, Xiong, T, Balen, J, Mc Manus, DP (2006) CD4+ T-cell counts, CD4+/CD8+ T-cell count ratios and antibody levels in migrant fishermen infected with Schistosoma japonicum in the Dongting Lake, China. Am J Trop Med Hyg 75: pp. 910-913
  24. Morsica, G, Tambussi, G, Sitia, G (1999) Replication of hepatitis C virus in B lymphocytes (CD19+). Blood 94: pp. 1138-1139
  25. Ito, M, Kusunoki, H, Mochida, K, Yamaguchi, K, Mizuochi, T (2011) HCV infection and B-cell lymphomagenesis. Clin Adv Hematol 2011: pp. 835314
  26. Pawe艂czykl, A, Kubisa, N, Jab艂o艅ska, J, Bukowska-O艣ko, I, Caraballo, K, Fic, M, Laskus, T, Radkowski, M (2013) Detection of hepatitis C virus (HCV) negative strand RNA and NS3 protein in peripheral blood mononuclear cells (PBMC): CD3+ , CD14+ and CD19+. J Virol 10: pp. 346
  27. Dessouki, O, Kamiya, Y, Nagahama, H (2010) Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment. Biochem Biophys Res Commun 393: pp. 331-7 2010.02.008" target="_blank" title="It opens in new window">CrossRef
  28. Blank, RB, Lamb, EW, Tocheva, AS, Crow, ET, Lim, KC, McKerrow, JH (2006) The common gamma chain cytokines IL-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis 194: pp. 1609-1616 CrossRef
  29. Jankovic, D, Cheever, AW, Kullberg, MC, Wynn, TA, Yap, G, Caspar, P (1998) CD4+ T cell mediated Granulomatous Pathology in Schistosomiasis is down regulated by a B cell dependent mechanism requiring fc receptor signaling. J Exp Med 187: pp. 619-629 CrossRef
  30. Pauline, NM, Lisa, M, Ganley-Leal, M, Daniel, G (2009) Circulating CD23+ B cell subset correlates with the development of resistance to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments. J Infect Dis 199: pp. 272-279 2" target="_blank" title="It opens in new window">CrossRef
  31. Pesce, JT, Ramalingam, TR, Wilson, MS, Mentink-Kane, MM, Thompson, RW, Cheever, AW, Urban, JF, Wynn, TA (2009) Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog 5: pp. e100039
  32. Hernandez, HJ, Wang, Y, Stadecker, MJ (1997) In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation. J Immunol 158: pp. 4832-4837
  33. Wen, T, Mingler, MK, Blanchard, C, Wahl, B, Pabst, O, Rothenberg, ME (2012) The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. J Immunol 188: pp. 1075-1082 2222" target="_blank" title="It opens in new window">CrossRef
  34. Monroe, DM, Hoffman, M (2009) The coagulation cascade in cirrhosis. Clin Liver Dis 13: pp. 1 2008.09.014" target="_blank" title="It opens in new window">CrossRef
  35. Golden-Mason, L, Castelblanco, N, O'Farrelly, C, Rosen, HR (2007) Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. J Virol 81: pp. 9292-9298 28/JVI.00834-07" target="_blank" title="It opens in new window">CrossRef
  36. Kawarabayashi, N, Seki, S, Hatsuse, K, Ohkawa, T, Koike, Y, Aihara, T, Habu, Y, Nakagawa, R, Ami, K, Hiraide, H, Mochizuki, H (2000) Decrease of CD56 (+) T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma. Hepatology 32: pp. 962-9 2000.19362" target="_blank" title="It opens in new window">CrossRef
  37. Corado, J, Toro, F, Rivera, H, Bianco, NE, Deibis, L, De Sanctis, JB (1997) Impairment of natural killer (NK) cytotoxic activity in hepatitis C virus (HCV) infection. Clin Exp Immunol 109: pp. 451-457 2249.1997.4581355.x" target="_blank" title="It opens in new window">CrossRef
  38. Hotho, D, Kreefft, K, Groothuismink, Z, Janssen, H, Knegt, R, Boonstra, A (2013) Natural killer cell activity and function in chronic HCV-infected patients during peg interferon and ribavirin: Early effects of active substance use. Antiviral Res 3: pp. 347-355 2012.12.025" target="_blank" title="It opens in new window">CrossRef
  39. Meier, U, Owen, R, Taylor, E, Worth, A, Naoumov, N, Willberg, C (2005) Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections. J Virol 79: pp. 12365-12374 28/JVI.79.19.12365-12374.2005" target="_blank" title="It opens in new window">CrossRef
  40. Li, N (2008) Platelet鈥搇ymphocyte cross-talk. J Leukoc Biol 83: pp. 1069-78 CrossRef
  41. Joseph, M, Auriault, C, Capron, A, Vorng, H, Viens, P (1983) A new function for platelets: IgE-dependent killing of schistosomes. Nature 303: pp. 810-812 CrossRef
  42. Hevessy, Z, Nagy, B, Kiss, F, Kiss, A, Kappelmayer, J (2005) Mean fluorescence intensity rate is a useful marker in the detection of paroxysmal nocturnal hemoglobinuria clones. Clin Chem Lab Med 43: pp. 919-923 2005.157" target="_blank" title="It opens in new window">CrossRef
  43. Laschke, MW, Dold, S, Menger, MD, Jeppsson, B, Thorlacius, H (2008) Platelet dependent accumulation of leukocytes in sinusoids mediates hepatocellular damage in bile duct ligation-induced cholestasis. Br J Pharmacol 153: pp. 148-156 CrossRef
  44. Giannini, EG (2006) Thrombocytopenia in chronic liver disease and pharmacologic treatment options. Aliment Pharmacol Ther 23: pp. 1055-1065 2036.2006.02889.x" target="_blank" title="It opens in new window">CrossRef
  45. Ameisen, JC, Joseph, M, Caen, JP, Kusnierz, JP, Capron, M, Boizard, B (1986) A role for glycoprotein Iib-IIIa complex in the binding of IgE to human platelets and platelet IgE dependent cytotoxic functions. Br J Haematol 64: pp. 21-32 2141.1986.tb07570.x" target="_blank" title="It opens in new window">CrossRef
  46. Zhang, Z, Wu, H, Chen, S, Hu, L, Xie, Z, Qiu, Y, Su, C, Cao, JP, Wu, Y, Zhang, S, Wu, G (1997) Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum. Trans R Soc Trop Med Hyg 91: pp. 606-8 203(97)90047-X" target="_blank" title="It opens in new window">CrossRef
  47. Gomes, Y, Pereira, V, Nakazawa, M, Montarroyos, U, Souza, W, Abath, F (2002) Antibody isotype responses to egg antigens in human chronic schistosomiasis mansoni before and after treatment. Mem Inst Oswaldo Cruz 97: pp. 111-112
  48. Guzm谩n-Fulgencio, M, Berenguer, J, de Castro, I, Micheloud, D, L贸pez, J, Cos铆n, J (2011) Sustained virological response to interferon-伪 plus ribavirin decreases inflammation and endothelial dysfunction markers in HIV/HCV co-infected patients. J Antimicrob Chemother 66: pp. 645-649 CrossRef
  49. Vardareli, E, Saricam, T, Demirustu, C, Gulbas, Z (2007) Soluble P-selectin levels in chronic liver disease: relationship to disease severity. Hepatogastroenterology 54: pp. 466-469
  50. Ferroni, P, Mammarella, A, Martini, F (2001) Increased soluble p-selectin levels in hepatitis C virus-related chronic hepatitis: correlation with viral load. J Investig Med 49: pp. 407-412 2310/6650.2001.33785" target="_blank" title="It opens in new window">CrossRef
  51. Koster, B, Strand, M (1994) Schistosoma mansoni: Immunolocalization of two different fucose-containing carbohydrate epitopes. Parasitology 108: pp. 433-446 2000075995" target="_blank" title="It opens in new window">CrossRef
  52. Springer, TA, Lasky, LA (1991) Cell adhesion Sticky sugars for selectins. Nature 349: pp. 196-197 CrossRef
  53. Mentink-Kane, MM, Cheever, AW, Thompson, RW, Hari, DM, Kabatereine, NB, Vennervald, BJ, Ouma, JH, Mwatha, JK, Jones, FM, Donaldson, DD, Grusby, MJ, Dunne, DW, Wynn, TA (2004) IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Nat Acad Sci 101: pp. 586-590 CrossRef
  54. Liu, Y, Munker, S, M眉llenbach, R, Weng, H (2012) IL13 signaling in liver fibrosis. Front Immunol 3: pp. 116 2012.00116" target="_blank" title="It opens in new window">CrossRef
  55. Gy枚rgy, B, Szab贸, TG, P谩szt贸i, M, P谩l, Z, Misj谩k, P, Aradi, B, L谩szl贸, V, P谩llinger, E, Pap, E, Kittel, A, Nagy, G, Falus, A, Buz谩s, EI (2011) Membrane vesicles, current state-of-the art: emerging role of extracellular vesicles. Cell Mol Life Sci 68: pp. 2667-2688 CrossRef
  56. W膮sik, M, Kawka, E, G贸rska, E, Walaszkiewicz-Majewska, B (2011) Quantitative and qualitative evaluation of platelets-derived micro vesicles. Centr Eur J Immunol 36: pp. 163-169
  57. The pre-publication history for this paper can be accessed here:230X/14/132/prepub" class="a-plus-plus">http://www.biomedcentral.com/1471-230X/14/132/prepub
  
• 刊物主题：Gastroenterology; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-230X

文摘

Background Hepatitis C virus (HCV) and Schistosoma mansoni are major causes of chronic liver disease (CLD) in which immune alteration is common. Recent studies suggested that certain platelets and lymphocytes activation markers may have an impact on progression of CLD. This study aimed to evaluate the potential of platelets and lymphocytes activation molecules expression on the pathogenesis of CLD in distinct or concomitant chronic HCV and schistosomiasis mansoni infections. Methods The study populations were divided into group-I: patients with chronic schistosomiasis mansoni, group-II: HCV patients without cirrhosis, group-III: patients with combined liver diseases without cirrhosis, group-IV: patients with chronic HCV and liver cirrhosis and group-V: Age and sex matched healthy individuals as normal controls. All groups were subjected to full clinical evaluation, ELISA anti-HCV antibodies screening, parasitological examination for diagnosing S. mansoni and flow cytometry for lymphocyte (CD3, CD4, CD8, CD19, CD22, & CD56) and platelets activation (CD41, CD42 & CD62P (P- selectins)) markers. Results The platelet count was significantly decreased in HCV and/or S. mansoni patients. The total T-lymphocytes and T-helper cells were significantly reduced, while T-cytotoxics were increased. The patients possessed a significantly higher platelets activation marker; CD62P (P-selectins) and higher mean fluorescent intensity (MFI) positivity. There were considerable correlations between platelets count and both of CD62P and MFI. Conclusion Our Findings suggest an increased expression of certain platelets and lymphocytes activation markers in chronic HCV and S. mansoni induced CLD that may have a role in disease progression.