Arterial remodeling of basilar atherosclerosis in isolated pontine infarction
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- 作者：Chao Feng (1) (2)
Ting Hua (3)
Yu Xu (3)
Xue-Yuan Liu (1)
Jing Huang (1)
1. Department of Neurology ; Shanghai Tenth People鈥檚 Hospital of Tongji University ; Middle Yanchang Rd. 301# ; Zhabei District ; Shanghai ; China
2. The Fourth Affiliated Hospital of Zhejiang University School of Medicine ; Yiwu ; Zhejiang ; China
3. Department of Radiology ; Shanghai Tenth People鈥檚 Hospital of Tongji University ; Shanghai ; China - 关键词：Paramedian pontine infarction ; Lacunar pontine infarction ; Basilar artery atherosclerosis ; Arterial remodeling ; High ; resolution MRI
- 刊名：Neurological Sciences
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：36
- 期：4
- 页码：547-551
- 全文大小：315 KB
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- 刊物主题：Medicine & Public Health
Neurology
Neuroradiology
Neurosurgery
Psychiatry - 出版者：Springer Milan
- ISSN：1590-3478
文摘
Isolated pontine infarctions are usually classified as paramedian pontine infarction (PPI) and lacunar pontine infarction (LPI). Although they have different shapes and locations, some recent studies proved that they might both be associated with basilar artery atherosclerosis in pathogenesis. This study aimed to explore the difference of basilar artery remodeling between two subtypes of pontine infarctions. Patients with PPI or LPI were scanned by High-resolution MRI (HR-MRI). The MR images of patients with basilar artery atherosclerosis were further analyzed to measure the vessel, lumen and wall areas at different segments of basilar arteries. Stenosis rate and remodeling index were calculated according to which arterial remodeling was divided into positive, intermediate and negative remodeling. Vascular risk factors and remodeling-related features were compared between PPI and LPI, and also between patients with and without positive remodeling. 34 patients with PPI and 21 patients with LPI had basilar artery atherosclerosis identified by HR-MRI. Positive remodeling was dominant in LPI group while in PPI group, three subtypes of remodeling were equal. Patients with positive remodeling had higher levels of low-density lipoprotein and homocysteine. Positive remodeling of basilar artery might reflect the low stability of basilar atherosclerotic plaques, which was more closely associated with LPI than PPI.