Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations

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• 作者：Xing Zhang (1)
  Yanyuan Li (2)
  Xiang Li (3)
  Wanjiang Zhang (4)
  Zhifen Pan (5)
  Fang Wu (4)
  Chong Wang (1)
  Zhongliang Chen (1)
  Tingting Jiang (1)
  Dandan Xu (1)
  Zepeng Ping (1)
  Jiyan Liu (1)
  Changming Liu (1)
  Zhongjie Li (1)
  Ji-Cheng Li (1)
  
  1. Institute of Cell Biology ; Zhejiang University ; No. 866 ; Yuhangtang Road ; Hangzhou ; 310058 ; China
  2. Department of Pathology ; First Affiliated Hospital ; Zhejiang University ; Hangzhou ; 310003 ; China
  3. Key Laboratory of Gastroenteropathy ; Zhejiang Province People鈥檚 Hospital ; Hangzhou ; 310012 ; China
  4. Department of Pathophysiology ; Shihezi University School of Medicine ; Xinjiang ; 832000 ; China
  5. Department of Tuberculosis ; Jiaxing First Hospital ; Jiaxing ; 314000 ; China
  
• 关键词：MicroRNAs ; Pulmonary tuberculosis ; Single ; nucleotide polymorphism ; Kazak ; Uygur ; Southern Han
• 刊名：BMC Infectious Diseases
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：790 KB
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• 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2334

文摘

Background Single nucleotide polymorphisms (SNPs) within precursor microRNAs (miRNAs) can affect miRNAs expression, and may be involved in the pathogenesis of pulmonary tuberculosis (TB). This study aimed to investigate potential associations between the four precursor miRNA SNPs (miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 T > C) and susceptibility to pulmonary TB in the Chinese Uygur, Kazak, and Southern Han populations. Methods A case-control study was performed on Chinese Uygur (n = 662), Kazak (n = 612), and Southern Han (n = 654) populations using the PCR-PFLR method. The allele and genotype frequencies for all populations were analyzed. Linkage disequilibrium was performed, and different models of inheritance were tested. Results The allele and genotype frequencies of the miR-499 SNP were significantly different between the TB patients group and the healthy control group in the Uygur population, and were found to be codominant, dominant, recessive and additive models in association with pulmonary TB. The haplotype CTCC showed significant correlation with pulmonary TB. The allele and genotype frequencies of miR-146a and miR-196a2 SNPs were significantly different between the two groups in the Kazak population. The miR-146a SNP was found to be codominant, recessive and additive models, whereas, the miR-196a2 SNP was found to be codominant, dominant, and additive models in association with pulmonary TB. The haplotypes TCCC and CCCT showed significant correlation with pulmonary TB. Conclusions The results suggested that susceptibility to pulmonary TB may be closely related to individual differences caused by genetic factors among different ethnic groups in China.