HExDB: a database for epigenetic changes occurring after horse exercise

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• 作者：Jeong-An Gim (1)
  Sugi Lee (2)
  Dae-Soo Kim (3)
  Kwang-Seuk Jeong (1) (4)
  Chang Pyo Hong (5)
  Jin-Han Bae (6)
  Jae-Woo Moon (5)
  Yong-Seok Choi (2)
  Byung-Wook Cho (7)
  Hwan-Gue Cho (8)
  Jong Bhak (5)
  Heui-Soo Kim (1)
  
  1. Department of Biological Sciences ; College of Natural Sciences ; Pusan National University ; Busan ; 609-735 ; Republic of Korea
  2. Department of Statistics ; College of Natural Sciences ; Pusan National University ; Busan ; 609-735 ; Republic of Korea
  3. Genome Resource Center ; Korea Research Institute of Bioscience and Biotechnology (KRIBB) ; 111 Gwahangno ; Yuseong-gu ; Daejeon ; 305-806 ; Republic of Korea
  4. Institute of Environmental Technology & Industry ; Pusan National University ; Busan ; 609-735 ; Republic of Korea
  5. TBI ; Theragen BiO Institute ; Theragen Etex ; Suwon ; 443-270 ; Republic of Korea
  6. Research Center ; Dongnam Institute of Radiological and Medical Sciences (DIRAMS) ; Busan ; Republic of Korea
  7. Department of Animal Science ; College of Life Sciences ; Pusan National University ; Miryang ; 627-702 ; Republic of Korea
  8. School of Computer Science and Engineering ; College of Engineering ; Pusan National University ; Busan ; 609-735 ; Republic of Korea
  
• 关键词：Thoroughbred horse ; Exercise ; Differentially methylated region ; Transposable element ; MeDIP ; Seq
• 刊名：Genes & Genomics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：37
• 期：3
• 页码：287-294
• 全文大小：4,908 KB
• 参考文献：1. Barres, R, Yan, J, Egan, B, Treebak, JT, Rasmussen, M, Fritz, T, Caidahl, K, Krook, A, O鈥橤orman, DJ, Zierath, JR (2012) Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab 15: pp. 405-411 CrossRef
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  4. Girardot, M, Guibert, S, Laforet, MP, Gallard, Y, Larroque, H, Oulmouden, A (2006) The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene. Pigment Cell Res 19: pp. 346-355 9.2006.00312.x" target="_blank" title="It opens in new window">CrossRef
  5. Hill, EW, McGivney, BA, Gu, J, Whiston, R, Machugh, DE (2010) A genome-wide SNP-association study confirms a sequence variant (g.66493737C聽>聽T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses. BMC Genom 11: pp. 552 CrossRef
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  8. McGivney, BA, McGettigan, PA, Browne, JA, Evans, AC, Fonseca, RG, Loftus, BJ, Lohan, A, MacHugh, DE, Murphy, BA, Katz, LM (2010) Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training. BMC Genom 11: pp. 398 98" target="_blank" title="It opens in new window">CrossRef
  9. McGivney, BA, Browne, JA, Fonseca, RG, Katz, LM, Machugh, DE, Whiston, R, Hill, EW (2012) MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance. Anim Genet 43: pp. 810-812 9.x" target="_blank" title="It opens in new window">CrossRef
  10. Park, KD, Park, J, Ko, J, Kim, BC, Kim, HS, Ahn, K, Do, KT, Choi, H, Kim, HM, Song, S (2012) Whole transcriptome analyses of six thoroughbred horses before and after exercise using RNA-Seq. BMC Genom 13: pp. 473 CrossRef
  11. Ronn, T, Volkov, P, Davegardh, C, Dayeh, T, Hall, E, Olsson, AH, Nilsson, E, Tornberg, A, Dekker Nitert, M, Eriksson, KF (2013) A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet 9: pp. e1003572 CrossRef
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• 刊物主题：Microbial Genetics and Genomics; Plant Genetics & Genomics; Animal Genetics and Genomics; Human Genetics;
• 出版者：Springer Netherlands
• ISSN：2092-9293

文摘

DNA methylation is an essential biochemical modification that regulates gene expression. Exercise induces changes in gene expression that adapt as metabolic changes in the blood. We provide a database for the epigenetic changes after horse exercise (http://www.primate.or.kr/hexdb). Horse Exercise Epigenetic Database (HExDB) explicates the change in genome-wide DNA methylation patterns after exercise. Exercise changes the genome-wide epigenetic patterns, and understanding the regions that change is important for confirming exercise physiological mechanisms. For this purpose, our database provides information on differentially methylated regions after exercise that pass a set threshold. A total of 784 genes based on NCBI RefSeq were identified as differentially methylated in equines after exercise. Our database provides clues for the study of exercise-related epigenetic pathways in the thoroughbred horse.