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Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders
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  • 作者:Norbert Laube (1) (2)
    Wolfgang Berg (3)
    Falk Bernsmann (2)
    Sascha Gravius (4)
    Florian Klein (5)
    Stefan Latz (6)
    Dirk von Mallek (7)
    Tadeusz Porowski (8)
    Thomas Randau (4)
    Anna Wasilewska (8)
    Christian Fisang (6)

    1. Deutsches Harnsteinzentrum
    ; Urologisches Zentrum Bonn Friedensplatz ; Friedensplatz 16 ; Bonn ; 53111 ; Germany
    2. NTTF Coatings GmbH
    ; Maarweg 32 ; Rheinbreitbach ; 53619 ; Germany
    3. Clinic and Policlinic of Urology
    ; Friedrich Schiller University of Jena ; Lessingstra脽e 1 ; Jena ; 07743 ; Germany
    4. Clinic for Orthopaedics and Trauma Surgery
    ; Friedrich-Wilhelms-Universit盲t Bonn ; Sigmund-Freud-Stra脽e 25 ; Bonn ; 53127 ; Germany
    5. FH Aachen
    ; Campus J眉lich ; FB Medizintechnik und Technomathematik ; Heinrich-Mu脽mann-Stra脽e 1 ; J眉lich ; 52428 ; Germany
    6. Clinic and Policlinic of Urology and Pediatric Urology
    ; Friedrich-Wilhelms-Universit盲t Bonn ; Sigmund-Freud-Stra脽e 25 ; Bonn ; 53127 ; Germany
    7. Department of Research
    ; Federal Institute for Drugs and Medical Devices (BfArM) ; Kurt-Georg-Kiesinger-Allee 3 ; Bonn ; 53175 ; Germany
    8. Department of Pediatrics and Nephrology
    ; Medical University of Bia艂ystok ul ; Waszyngtona 17 ; Bia艂ystok ; 15-546 ; Poland
  • 关键词:Urinary crystal formation ; Metabolic diseases ; Disease/treatment monitoring ; Predictive preventive personalised medicine ; Bonn ; Risk ; Index ; Nephropathies ; Meno ; /andropause
  • 刊名:The EPMA Journal
  • 出版年:2014
  • 出版时间:December 2014
  • 年:2014
  • 卷:5
  • 期:1
  • 全文大小:2,398 KB
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  • 刊物主题:Biomedicine general; Medicine/Public Health, general;
  • 出版者:BioMed Central
  • ISSN:1878-5085
文摘
Crystal formation reflects the entire composition of the surrounding solution. In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis. If the progression of a disease is associated with characteristic changes in the activities of urinary components, this leads to an altered urinary crystallisation capacity. Therefore, the results of induced urinary crystal formation can be used to detect and monitor any disease linked to the altered urinary composition. Since crystal formation inherently takes into account the entire urinary composition, the influence of the disease on individual urinary parameters does not have to be known in order to monitor the consequent pathologic alterations. In this paper, we review the background of urinary crystal formation analysis and describe its established application in urolithiasis monitoring as well as potential further fields of clinical application.

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