High hopes for cannabinoid agonists in the treatment of rheumatic diseases

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• 作者：Caroline A Staunton (7)
  Ali Mobasheri (10) (11) (8) (9)
  Richard Barrett-Jolley (7) (8)
  
  7. Department of Musculoskeletal Biology ; Institute of Ageing and Chronic Disease ; University of Liverpool ; Liverpool ; L69 3GA ; United Kingdom
  10. School of Veterinary Medicine ; Faculty of Health and Medical Sciences ; University of Surrey ; Duke of Kent Building ; Guildford ; Surrey ; GU2 7XH ; UK
  11. Arthritis Research UK Centre for Sport ; Exercise and Osteoarthritis ; Arthritis Research UK Pain Centre ; Medical Research Council and Arthritis Research UK Centre for Musculoskeletal Ageing Research ; University of Nottingham ; Queen鈥檚 Medical Centre ; Nottingham ; NG7 2UH ; UK
  8. The D-BOARD European Consortium for Biomarker Discovery ; School of Veterinary Medicine ; Faculty of Health and Medical Sciences ; University of Surrey ; Duke of Kent Building ; Guildford ; Surrey ; GU2 7XH ; UK
  9. Center of Excellence in Genomic Medicine Research (CEGMR) ; King Fahd Medical Research Center (KFMRC) ; King Abdul Aziz University ; Jeddah ; 21589 ; Kingdom of Saudi Arabia
  
• 关键词：Cannabinoids ; Cannabis ; Chronic pain ; Dorsal root ganglia ; Ion channels ; Fibroblast ; like synoviocytes (FLS) ; JW133 ; Osteoarthritis (OA) ; Rheumatoid Arthritis (RA)
• 刊名：BMC Musculoskeletal Disorders
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：537 KB
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  40. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2474/15/410/prepub
  
• 刊物主题：Orthopedics; Rehabilitation; Rheumatology; Sports Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2474

文摘

There are two well-characterised isoforms of cannabinoid receptor; CB1 and CB2 and of these CB2 is under active investigation as a potential target for treatment of the chronic pain associated with widespread and intractable joint diseases osteoarthritis and rheumatoid arthritis. The recent report by Fukuda et al (BMC Musculoskelet Disord 15:275, 2014) in BMC Musculoskeletal Disorders investigates the efficacy of a selective CB2 agonist, JW133, in both in vitro and in vivo models of rheumatoid arthritis and provides encouraging data. The report shows that JW133 inhibits expression of the CCL2 cytokine, osteoclastogenesis and reduces histological indicators of joint degeneration. Each of these could potentially contribute to beneficial analgesic effects in a therapeutic context.