Orbital dermatofibrosarcoma protuberans with intracranial extension preceded by recurrent leiomyoma of the orbit: a case report
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- 作者：Sanaullah Bashir ; Maryam Tariq ; Hafiz Muhammad Aslam…
- 关键词：Dermatofibrosarcoma protuberans ; Leiomyoma ; Orbital tumors ; Soft tissue tumors
- 刊名：Journal of Medical Case Reports
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：9
- 期：1
- 全文大小：841 KB
- 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Public Health; Primary Care Medicine;
- 出版者：BioMed Central
- ISSN：1752-1947
文摘
Introduction Dermatofibrosarcoma protuberans is a rare, locally aggressive cutaneous tumor of intermediate to low-grade malignancy. COL1A1-PDGFβ translocation is specific to dermatofibrosarcoma protuberans, where the abnormally fused COL1A1-PDGFβ gene directs formation of an abnormal combined (fusion) protein that researchers believe to ultimately function like the platelet-derived growth factor-beta protein.