Pseudomembranous Type of Oral Candidiasis is Associated with Decreased Salivary Flow Rate and Secretory Immunoglobulin A Levels

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• 作者：Bela Mahajan ; Neeta Bagul ; Rajiv Desai ; Mamatha Reddy ; Amit Mahajan…
• 关键词：Oral candidiasis ; HIV ; positive ; Salivary flow rate ; Secretory IgA
• 刊名：Mycopathologia
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：180
• 期：1-2
• 页码：75-80
• 全文大小：375 KB
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• 作者单位：Bela Mahajan (1)
  Neeta Bagul (1)
  Rajiv Desai (1)
  Mamatha Reddy (1)
  Amit Mahajan (1)
  Ashwini Shete (2)
  Arun Risbud (2)
  Arati Mane (2)
  
  1. DY Patil Dental College and Hospital, Pune, India
  2. National AIDS Research Institute, 73 ‘G-Block, MIDC, Bhosari, Pune, 411026, Maharashtra, India
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Medical Microbiology
  Plant Sciences
  Microbial Ecology
  
• 出版者：Springer Netherlands
• ISSN：1573-0832

文摘

Saliva plays an important role in maintaining microbial homeostasis in the oral cavity, while salivary gland hypofunction predisposes the oral mucosa to pathologic alteration and increases the risk for oral candidiasis. This study sought to determine the salivary flow rate (SFR) and secretory immunoglobulin A (SIgA) levels in HIV-positive and HIV-negative individuals and evaluate their relationship with the determinants of oral candidiasis. Sixty HIV-positive (30 with and 30 without oral candidiasis) and 30 healthy HIV-negative individuals were enrolled. Cotton pellet was weighed pre- and post-saliva collection for the assessment of SFR, while SIgA levels were estimated by commercial ELISA (Diametra, Italy) kit. The mean?±?SD, SFR and SIgA levels in HIV-positive individuals with candidiasis, without candidiasis and HIV-negative controls were 0.396?±?0.290, 0.546?±?0.355 and 0.534?±?0.214?ml/min and 115.891?±?37.621, 136.024?±?51.075 and 149.418?±?31.765?μg/ml, respectively. A positive correlation between low CD4 counts (indicator of immunodeficiency) and SIgA was observed in HIV-positive individuals with candidiasis (r?=?0.373, p?=?0.045). We also report here for the first time the significant decrease in SFR and SIgA levels in individuals presenting with pseudomembranous type of oral candidiasis and Candida albicans infection.