The roles of endoplasmic reticulum stress response in female mammalian reproduction

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• 作者：Yanzhou Yang ; Xiuying Pei ; Yaping Jin ; Yanrong Wang…
• 关键词：Endoplasmic reticulum stress response ; Follicle atresia ; Embryo implantation ; Decidualization ; Embryonic development ; Placental development
• 刊名：Cell and Tissue Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：363
• 期：3
• 页码：589-597
• 全文大小：725 KB
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• 作者单位：Yanzhou Yang (1)
  Xiuying Pei (1)
  Yaping Jin (3)
  Yanrong Wang (1)
  Cheng Zhang (2)
  
  1. Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, 75004, People’s Republic of China
  3. Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China
  2. College of Life Science, Capital Normal University, Beijing, 100048, Peoples’ Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Endoplasmic reticulum stress (ERS) activates a protective pathway, called the unfold protein response, for maintaining cellular homeostasis, but cellular apoptosis is triggered by excessive or persistent ERS. Several recent studies imply that the ERS response might have broader physiological roles in the various reproductive processes of female mammals, including embryo implantation, decidualization, preimplantation embryonic development, follicle atresia, and the development of the placenta. This review summarizes the existing data concerning the molecular and biological roles of the ERS response. The study of the functions of the ERS response in mammalian reproduction might provide novel insights into and an understanding of reproductive cell survival and apoptosis under physiological and pathological conditions. The ERS response is a novel signaling pathway for reproductive cell survival and apoptosis. Infertility might be a result of disturbing the ERS response during the process of female reproduction.