Supplementation with dairy calcium and/or flaxseed fibers in conjunction with orlistat augments fecal fat excretion without altering ratings of gastrointestinal comfort

详细信息    查看全文

• 作者：Mette Kristensen ; Signe Rømer Juul ; Karina Vejrum Sørensen…
• 关键词：Orlistat ; Flaxseed ; Calcium ; Side effects ; Weight loss ; Obesity
• 刊名：Nutrition & Metabolism
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：701KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Clinical Nutrition; Metabolic Diseases;
• 出版者：BioMed Central
• ISSN：1743-7075
• 卷排序：14

文摘

BackgroundOrlistat is a lipase inhibitor which reduced absorption of dietary fat by ~30% thereby inducing a weight loss; however, side effects occur as a consequence of increased colonic fat content. To test the hypothesis that most gastrointestinal side events induced by treatment with orlistat could be prevented/ameliorated by concomitant use of natural dietary components, flaxseed fiber (FF) and/or dairy calcium (Ca), binding liquid fats to more solid complexes.