Marrow adipocytes inhibit the differentiation of mesenchymal stem cells into osteoblasts via suppressing BMP-signaling
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- 作者：Basem M. Abdallah
- 关键词：Mesenchymal stem cells ; BMSCs ; Osteoblast ; Adipocyte ; Paracrine factors ; osteoblast differentiation
- 刊名：Journal of Biomedical Science
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：24
- 期：1
- 全文大小：1129KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine, general;
- 出版者：BioMed Central
- ISSN：1423-0127
- 卷排序：24
文摘
BackgroundReduced bone formation is associated with increased bone marrow fat in many bone-loss related diseases including aging, post-menopause, and anorexia nervosa. Several lines of evidence suggested the regulation of osteogenesis and adipogenesis of the bone marrow-derived mesenchymal (skeletal) stem cells (BMSCs) by paracrine mediators. This study aimed to investigate the impact of adipocytes-secreted factors on the cell proliferation and osteoblast differentiation of BMSCs.