SOX5 is involved in balanced MITF regulation in human melanoma cells
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- 作者：Theresa Kordaß ; Claudia E. M. Weber ; Marcus Oswald ; Volker Ast…
- 关键词：SOX5 ; MITF ; SOX10 ; Melanoma ; Mixed Integer Linear Programming ; Regulatory models
- 刊名：BMC Medical Genomics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：9
- 期：1
- 全文大小：1,599 KB
- 刊物主题：Human Genetics; Microarrays;
- 出版者：BioMed Central
- ISSN：1755-8794
文摘
Background Melanoma is a cancer with rising incidence and new therapeutics are needed. For this, it is necessary to understand the molecular mechanisms of melanoma development and progression. Melanoma differs from other cancers by its ability to produce the pigment melanin via melanogenesis; this biosynthesis is essentially regulated by microphthalmia-associated transcription factor (MITF). MITF regulates various processes such as cell cycling and differentiation. MITF shows an ambivalent role, since high levels inhibit cell proliferation and low levels promote invasion. Hence, well-balanced MITF homeostasis is important for the progression and spread of melanoma. Therefore, it is difficult to use MITF itself for targeted therapy, but elucidating its complex regulation may lead to a promising melanoma-cell specific therapy.