Antiangiogenic actions of heparin derivatives for cancer therapy

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• 作者：Hae Hyun Hwang ; Dong Yun Lee
• 关键词：heparin derivatives ; anticancer ; bile acid ; protein ; metal nanoparticle
• 刊名：Macromolecular Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：24
• 期：9
• 页码：767-772
• 全文大小：428 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Physical Chemistry
  Polymer Sciences
  Characterization and Evaluation of Materials
  Soft and Granular Matter, Complex Fluids and Microfluidics
  Nanochemistry
  Nanotec
  
• 出版者：The Polymer Society of Korea, co-published with Springer
• ISSN：2092-7673
• 卷排序：24

文摘

Heparin is widely used as an anticoagulant agent in clinical medication. Recent studies have reported that heparin could have anticancer effects due to its interaction with angiogenesis-related molecules, meaning that it could reduce the formation of new blood vessels and tumorigenesis in the body. However, when heparin is administered for long periods, it can cause heparin-induced thrombocytopenia (HIT) and bleeding due to its anticoagulant activity. To overcome this limitation, heparin derivatives have been developed by modification of their structure or by conjugation with functional groups. Here we reviewed several kinds of heparin derivatives using bile acids, proteins, and metal nanoparticles in terms of angiogenesis. These heparin derivatives are promising candidates for new anticancer treatments.Keywordsheparin derivativesanticancerbile acidproteinmetal nanoparticleReferences(1).S. W. Chung, S. M. Bae, M. Lee, T. A. Al-Hilal, C. K. Lee, J. K. Kim, I. S. Kim, S. Y. Kim, and Y. 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Norrby, APMIS, 114, 79 (2006).CrossRefGoogle ScholarCopyright information© The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016Authors and AffiliationsHae Hyun Hwang1Dong Yun Lee1Email author1.Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science & Technology (INST)Hanyang UniversitySeoulKorea About this article CrossMark Print ISSN 1598-5032 Online ISSN 2092-7673 Publisher Name The Polymer Society of Korea About this journal Reprints and Permissions Article actions function trackAddToCart() { var buyBoxPixel = new webtrekkV3({ trackDomain: "springergmbh01.webtrekk.net", trackId: "196033507532344", domain: "link.springer.com", contentId: "springer_com.buybox", product: "10.1007/s13233-016-4111-8_Antiangiogenic actions of heparin ", productStatus: "add", productCategory : { 1 : "ppv" }, customEcommerceParameter : { 9 : "link.springer.com" } }); buyBoxPixel.sendinfo(); } function trackSubscription() { var subscription = new webtrekkV3({ trackDomain: "springergmbh01.webtrekk.net", trackId: "196033507532344", domain: "link.springer.com", contentId: "springer_com.buybox" }); subscription.sendinfo({linkId: "inst. subscription info"}); } window.addEventListener("load", function(event) { var viewPage = new webtrekkV3({ trackDomain: "springergmbh01.webtrekk.net", trackId: "196033507532344", domain: "link.springer.com", contentId: "SL-article", product: "10.1007/s13233-016-4111-8_Antiangiogenic actions of heparin ", productStatus: "view", productCategory : { 1 : "ppv" }, customEcommerceParameter : { 9 : "link.springer.com" } }); viewPage.sendinfo(); }); Log in to check your access to this article Buy (PDF)EUR 34,95 Unlimited access to full article Instant download (PDF) Price includes local sales tax if applicable Find out about institutional subscriptions Export citation .RIS Papers Reference Manager RefWorks Zotero .ENW EndNote .BIB BibTeX JabRef Mendeley Share article Email Facebook Twitter LinkedIn Cookies We use cookies to improve your experience with our site. 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