Post-transcriptional regulation of long noncoding RNAs in cancer
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- 作者：Xuefei Shi (1)
Ming Sun (2)
Ying Wu (1)
Yanwen Yao (1)
Hongbing Liu (1)
Guannan Wu (1)
Dongmei Yuan (1)
Yong Song (1)
1. Department of Respiratory Medicine ; Jinling Hospital ; Nanjing University School of Medicine ; 305 East Zhongshan Road ; Nanjing ; 210002 ; Jiangsu Province ; China
2. Department of Biochemistry and Molecular Biology ; Nanjing Medical University ; Nanjing ; China - 关键词：Long noncoding RNA ; Mechanism ; Post ; transcriptional regulation ; Cancer
- 刊名：Tumor Biology
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：36
- 期：2
- 页码：503-513
- 全文大小：3,478 KB
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- 出版者：Springer Netherlands
- ISSN：1423-0380
文摘
It is a great surprise that the genomes of mammals and other eukaryotes harbor many thousands of long noncoding RNAs (lncRNAs). Although these long noncoding transcripts were once considered to be simply transcriptional noise or cloning artifacts, multiple studies have suggested that lncRNAs are emerging as new players in diverse human diseases, especially in cancer, and that the molecular mechanisms of lncRNAs need to be elucidated. More recently, evidence has begun to accumulate describing the complex post-transcriptional regulation in which lncRNAs are involved. It was reported that lncRNAs can be implicated in degradation, translation, pre-messenger RNA (mRNA) splicing, and protein activities and even as microRNAs (miRNAs) sponges in both a sequence-dependent and sequence-independent manner. In this review, we present an updated vision of lncRNAs and summarize the mechanism of post-transcriptional regulation by lncRNAs, providing new insight into the functional cellular roles that they may play in human diseases, with a particular focus on cancers.