Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

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• 作者：Bora Mun ; Weihong Wang ; Hiyoung Kim ; Dongyup Hahn…
• 关键词：5α ; 8α ; epidioxy sterol ; Monanchora sp. ; Cytotoxicity ; Pancreatic cancer ; Renal cancer ; Colorectal cancer
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：38
• 期：1
• 页码：18-25
• 全文大小：293 KB
• 参考文献：1. Berlinck, R.G.S., J.C. Braekman, and D. Daloze. 1992. Crambines C1 and C2: Two further ichthyotoxic guanidine alkaloids from the sponge / Crambe crambe. / Journal of Natural Products 55: 528-32. CrossRef
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  3. Chang, L.C., N.F. Whittaker, and C.A. Bewley. 2003. Crambescidin 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge / Monanchora sp. / Journal of Natural Products 66: 1490-494. CrossRef
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  7. Gross, H., and G.M. K?nig. 2006. Terpenoids from marine organisms: unique structures and their pharmacological potential. / Phytochemistry Reviews 5: 115-41. CrossRef
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  12. Im, K.S., K.I. Nam, C.J. Sim, and W.H. Jung. 2000. Sterol peroxide derivatives from the marine sponge / Spirastella abata. / Korean Journal of Pharmacognosy 31: 401-06.
  13. Ioannou, E., A.F. Abdel-Razik, M. Zervou, D. Christofidis, X. Alexi, C. Vagias, M.N. Alexis, and V. Roussis. 2009. 5α,8α-Epidioxysterols from the gorgonian / Eunicella cavolini and the ascidian / Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity. / Steroids 74: 73-0. CrossRef
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  15. Kahlos, K., L. Kangas, and R. Hiltunen. 1989. Ergosterol peroxide an active compound from / Inonotus radiatus. / Pl
• 作者单位：Bora Mun (1)
  Weihong Wang (1)
  Hiyoung Kim (1)
  Dongyup Hahn (1)
  Inho Yang (1)
  Dong Hwan Won (1)
  Eun-hee Kim (1)
  Jihye Lee (1)
  Chulkyeong Han (1)
  Hyunji Kim (1)
  Merrick Ekins (2)
  Sang-Jip Nam (3)
  Hyukjae Choi (4)
  Heonjoong Kang (1) (5)
  
  1. Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea
  2. Queensland Museum, South Brisbane BC, QLD, 4101, Australia
  3. Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Republic of Korea
  4. College of Pharmacy, Yeungnam University, 280, Daehak-ro, Gyeongsan, 712-749, Republic of Korea
  5. Research Institute of Oceanography, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-strong class="a-plus-plus">7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-strong class="a-plus-plus">7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.