Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial

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• 作者：K. Kalinsky ; T. Zheng ; H. Hibshoosh ; X. Du ; P. Mundi…
• 关键词：Pre ; surgical ; Metformin ; Reverse Phase Protein Array ; Immunohistochemistry ; Breast Cancer ; Cyclin D1
• 刊名：Clinical and Translational Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：2
• 页码：180-188
• 全文大小：
• 刊物主题：Oncology;
• 出版者：Springer International Publishing
• ISSN：1699-3055
• 卷排序：19

文摘

PurposeReverse Phase Protein Array (RPPA) is a high-throughput antibody-based technique to assess cellular protein activity. The goal of this study was to assess protein marker changes by RPPA in tumor tissue from a pre-surgical metformin trial in women with operable breast cancer (BC).