Serologic Responses in Indeterminate Colitis Patients Before Ileal Pouch-Anal Anastomosis May Determine Those at Risk for Continuous Pouch Inflammation

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• 作者：Thomas Hui ; Carol Landers ; Eric Vasiliauskas ; Maria Abreu ; Marla Dubinsky ; Konstantinos A. Papadakis ; Joanne Price ; Ying-Chao Lin ; Yang Huiying and Stephan Targan ; et al.
• 关键词：Ileal pouch ; anal anastomosis ; Pouchitis ; Indeterminate colitis ; Serologic markers
• 刊名：Diseases of the Colon & Rectum
• 出版年：2005
• 出版时间：June 2005
• 年：2005
• 卷：48
• 期：6
• 页码：1254-1262
• 全文大小：173 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Gastroenterology
  Oncology
  Surgical Oncology
  Colorectal Surgery
  
• 出版者：Springer New York
• ISSN：1530-0358

文摘

PURPOSE Although acute pouchitis after ileal pouch-anal anastomosis is common and easily treated, continuous pouch inflammation seen clinically as chronic, antibiotic-dependent pouchitis, and/or Crohn’s disease remains a difficult management problem. Compared with ulcerative colitis, indeterminate colitis patients undergoing ileal pouch-anal anastomosis have a higher incidence of continuous pouch inflammation, which may represent persistent immune reactivity to microbial antigens. Antibody responses to three microbial antigens (oligomannan anti-Saccharomyces cerevisiae, outer membrane porin C of Escherichia coli, and an antigen (I2) from Pseudomonas flourescens) are more commonly seen in Crohn’s disease, whereas antibodies to a cross-reactive antigen (perinuclear antineutrophil cytoplasmic antibodies) is more suggestive of ulcerative colitis. We examined whether preoperative serologic responses to these antigens were associated with Crohn’s disease in indeterminate colitis patients after ileal pouch-anal anastomosis.