Liver dysfunction as predictor of prognosis in patients with amyloidosis: utility of the Model for End-stage Liver disease (MELD) scoring system

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• 作者：Francesco Cappelli ; Samuele Baldasseroni…
• 关键词：Amyloid ; Prognosis ; MELD ; Liver dysfunction
• 刊名：Internal and Emergency Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：12
• 期：1
• 页码：23-30
• 全文大小：
• 刊物主题：Internal Medicine;
• 出版者：Springer Milan
• ISSN：1970-9366
• 卷排序：12

文摘

Amyloidosis prognosis is often related to the onset of heart failure and a worsening that is concomitant with kidney–liver dysfunction; thus the Model for End-stage Liver disease (MELD) may be an ideal instrument to summarize renal–liver function. Our aim has been to test the MELD score as a prognostic tool in amyloidosis. We evaluated 128 patients, 46 with TTR-related amyloidosis and 82 with AL amyloidosis. All patients had a complete clinical and echocardiography evaluation; overall biohumoral assessment included troponin I, NT-proBNP, creatinine, total bilirubin and INR ratio. The study population was dichotomized at the 12 cut-off level of MELD scores; those with MELD score >12 had a lower survival compared to controls in the study cohort (40.7 vs 66.3 %; p = 0.006). Either as a continuous and dichotomized variable, MELD shows its independent prognostic value at multivariable analysis (HR = 1.199, 95 % CI 1.082–1.329; HR = 2.707, 95 % CI 1.075–6.817, respectively). MELD shows a lower prognostic sensitivity/specificity ratio than troponin I and NT-proBNP in the whole study population and AL subgroup, while in TTR patients MELD has a higher sensitivity/specificity ratio compared to troponin and NT-proBNP (ROC analysis-AUC: 0.853 vs 0.726 vs 0.659). MELD is able to predict prognosis in amyloidosis. A MELD score >12 selects a subgroup of patients with a higher risk of death. The predictive accuracy seems to be more evident in TTR patients in whom currently no effective scoring systems have been validated.