Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells
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- 作者：Dong-Mi Shin (1)
Kyeong-Mi Choi (1)
Youn-Sun Lee (1)
Wonkyun Kim (1)
Kyong-Oh Shin (1)
Seikwan Oh (2)
Jae-Chul Jung (3)
Mi Kyeong Lee (1)
Yong-Moon Lee (1)
Jin Tae Hong (1)
Yeo-Pyo Yun (1)
Hwan-Soo Yoo (1) - 关键词：Echinacea purpurea ; 3T3 ; L1 cells ; Adipocyte differentiation ; Insulin ; Dodeca ; 2(E) ; 4(E) ; dienoic acid isobutylamide
- 刊名：Archives of Pharmacal Research
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：37
- 期：6
- 页码：803-812
- 全文大小：
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Kyeong-Mi Choi (1)
Youn-Sun Lee (1)
Wonkyun Kim (1)
Kyong-Oh Shin (1)
Seikwan Oh (2)
Jae-Chul Jung (3)
Mi Kyeong Lee (1)
Yong-Moon Lee (1)
Jin Tae Hong (1)
Yeo-Pyo Yun (1)
Hwan-Soo Yoo (1)
1. College of Pharmacy and Center for Innovative Cancer Therapeutics, Chungbuk National University, 52 Naesudong-ro, Heungduk-gu, Cheongju, 361-763, Republic of Korea
2. Department of Neuroscience and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
3. Rexgene Biotech Co., Ltd, Ochang, Republic of Korea - ISSN：1976-3786
文摘
Echinacea purpurea has been shown to have anti-diabetic activities; for example, it activates peroxisome proliferator-activated receptor γ (PPARγ) and increases insulin-stimulated glucose uptake. Adipogenesis has been used to study the insulin signaling pathway and to screen anti-diabetic compounds. The present study was conducted to investigate the effects of an ethanol extract of E. purpurea (EEEP) and its constituents on the insulin-induced adipocyte differentiation of 3T3-L1 preadipocytes. When adipocyte differentiation was induced with insulin plus 3-isobutyl-1-methylxanthine and dexamethasone, the accumulation of lipid droplets and the cellular triglyceride content were significantly increased by EEEP. The expressions of PPARγ and C/EBPα in adipocytes treated with EEEP were gradually increased as compared with control cells. Fat accumulation and triglyceride content of adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly increased as compared with control cells. The expressions of PPARγ and C/EBPα in adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly higher than in control cells. These results suggest EEEP promotes the adipogenesis that is partially induced by insulin and that dodeca-2(E),4(E)-dienoic acid isobutylamide appears to be responsible for EEEP-enhanced adipocyte differentiation.