Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro

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• 作者：Ha-Yeong Kim ; Hye Mi Kim ; Byeol Ryu ; Jae-Seung Lee…
• 关键词：Eclipta prostrata ; Terthiophene ; Triterpenoid ; Cytotoxicity ; Ovarian cancer
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：38
• 期：11
• 页码：1963-1969
• 全文大小：527 KB
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• 作者单位：Ha-Yeong Kim (1)
  Hye Mi Kim (2)
  Byeol Ryu (1)
  Jae-Seung Lee (1)
  Jung-Hye Choi (1) (2)
  Dae Sik Jang (1) (2)
  
  1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea
  2. College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

A new terthiophene, 3′-hydroxy-2,2′:5′,2″-terthiophene-3′-O-β-d-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-d-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2–6), seven triterpenoids (8–14), two coumestans (15 and 16), and four flavonoids (17–20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1–20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.