Dosimetric study of radium-223 chloride and 153Sm-EDTMP for treatment of bone metastases using MCNPX code and available experimental data

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• 作者：R. Bagheri ; H. Afarideh…
• 关键词：Bone metastases ; Radium ; 223 ; Absorbed and equivalent dose ; MCNPX
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：303
• 期：3
• 页码：1991-1998
• 全文大小：493 KB
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• 作者单位：R. Bagheri (1)
  H. Afarideh (1)
  M. Ghannadi-Maragheh (2)
  A. Bahrami-Samani (2)
  S. P. Shirmardi (2)
  
  1. Faculty of Energy Engineering and Physics, Amirkabir University of Technology, PO Box 15875-4413, Tehran, Iran
  2. Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, PO Box 14155-1339, Tehran, Iran
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

Radium-223 chloride is an alpha emitter radiopharmaceutical which recently has been used for treatment of bone metastases. Absorbed and equivalent doses of 223RaCl2 were studied using MCNPX Monte Carlo code in a phantom consisted of bone marrow, bone and soft tissue. 153Sm-EDTMP as a beta emitter was also simulated for comparison with 223RaCl2. Results show that by injection of 100?μCi 223RaCl2 against 70?mCi 153Sm-EDTMP to a 70?kg adult man, equivalent dose of metastatic bone can be increased about six times without significant increase in delivered dose to healthy tissues. These results demonstrated acceptable agreement with experimental data.