Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells

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• 作者：Hongcheng Zhu (1)
  Xi Yang (1)
  Jia Liu (1)
  Lu Zhou (2)
  Chi Zhang (1)
  Liping Xu (1)
  Qin Qin (1)
  Liangliang Zhan (1)
  Jing Lu (1)
  Hongyan Cheng (3)
  Xinchen Sun (1)
  
• 关键词：Eukaryotic elongation factor 2 kinase ; eEF2K ; eEF2 ; Cancer ; Stress
• 刊名：Cell Stress and Chaperones
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：20
• 期：2
• 页码：217-220
• 全文大小：119 KB
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• 作者单位：Hongcheng Zhu (1)
  Xi Yang (1)
  Jia Liu (1)
  Lu Zhou (2)
  Chi Zhang (1)
  Liping Xu (1)
  Qin Qin (1)
  Liangliang Zhan (1)
  Jing Lu (1)
  Hongyan Cheng (3)
  Xinchen Sun (1)
  
  1. Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  2. Department of Neurosurgery, Nanjing Drum Tower Hospital and Clinical College of Nanjing Medical University, Nanjing, China
  3. Department of General Internal Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  
• 刊物主题：Biomedicine general; Cell Biology; Biochemistry, general; Immunology; Cancer Research; Neurosciences;
• 出版者：Springer Netherlands
• ISSN：1466-1268

文摘

Eukaryotic elongation factor 2 (eEF2) is a member of the GTP-binding translation elongation factor family that is essential for protein synthesis. eEF2 kinase (eEF2K) is a structurally and functionally unique protein kinase in the calmodulin-mediated signaling pathway. eEF2K phosphorylates eEF2, thereby inhibiting eEF2 function under stressful conditions. eEF2K regulates numerous processes, such as protein synthesis, cell cycle progression, and induction of autophagy and apoptosis in cancer cells. This review will demonstrate the mechanisms underlying eEF2K activity in cancer cells under different stresses, such as nutrient deprivation, hypoxia, and DNA damage via eEF2 regulation. In vivo, in vitro, and clinical studies indicated that eEF2K may be a novel biomarker and therapeutic target for cancer.