A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle
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- 作者：Eiliv Lund ; Lars Holden ; Hege Bøvelstad…
- 关键词：Transcriptomics ; Gene expression ; NOWAC postgenome cohort ; Breast cancer ; Carcinogenesis ; Metastasis ; Mammographic screening ; Blood ; Systems epidemiology
- 刊名：BMC Medical Research Methodology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：1,333 KB
- 刊物主题：Theory of Medicine/Bioethics; Statistical Theory and Methods; Statistics for Life Sciences, Medicine, Health Sciences;
- 出版者：BioMed Central
- ISSN：1471-2288
文摘
Background The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of genes, based on measurements from many case-control pairs. We propose a new statistical method that does not assume any parametric shape for the gene trajectories.