Altering Genomic Integrity: Heavy Metal Exposure Promotes Transposable Element-Mediated Damage

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• 作者：Maria E. Morales ; Geraldine Servant ; Catherine Ade…
• 关键词：Transposable element ; Retroelement ; Heavy metals ; Genetic damage
• 刊名：Biological Trace Element Research
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：166
• 期：1
• 页码：24-33
• 全文大小：1,025 KB
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• 作者单位：Maria E. Morales (1)
  Geraldine Servant (1)
  Catherine Ade (2)
  Astrid M. Roy-Engel (1)
  
  1. Department of Epidemiology and Tulane Cancer Center, SL-66, Tulane University Health Sciences Center, 1430 Tulane Ave., New Orleans, LA, 70112, USA
  2. Department of Cellular and Molecular Biology, Tulane University Health Sciences Center, 1430 Tulane Ave., New Orleans, LA, 70112, USA
  
• 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
• 出版者：Springer US
• ISSN：1559-0720

文摘

Maintenance of genomic integrity is critical for cellular homeostasis and survival. The active transposable elements (TEs) composed primarily of three mobile element lineages LINE-1, Alu, and SVA comprise approximately 30?% of the mass of the human genome. For the past 2 decades, studies have shown that TEs significantly contribute to genetic instability and that TE-caused damages are associated with genetic diseases and cancer. Different environmental exposures, including several heavy metals, influence how TEs interact with its host genome increasing their negative impact. This mini-review provides some basic knowledge on TEs, their contribution to disease, and an overview of the current knowledge on how heavy metals influence TE-mediated damage.