Transposable element polymorphisms recapitulate human evolution
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- 作者：Lavanya Rishishwar ; Carlos E. Tellez Villa ; I. King Jordan
- 关键词：Transposable elements ; Polymorphism ; Population genetics ; Human ancestry ; Admixture ; Ancestry informative markers ; Phylogenetics ; Alu ; L1 ; SVA
- 刊名：Mobile DNA
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：6
- 期：1
- 全文大小：2,318 KB
- 刊物主题：Human Genetics; Animal Genetics and Genomics; Plant Genetics & Genomics; Developmental Biology;
- 出版者：BioMed Central
- ISSN：1759-8753
文摘
Background The human genome contains several active families of transposable elements (TE): Alu, L1 and SVA. Germline transposition of these elements can lead to polymorphic TE (polyTE) loci that differ between individuals with respect to the presence/absence of TE insertions. Limited sets of such polyTE loci have proven to be useful as markers of ancestry in human population genetic studies, but until this time it has not been possible to analyze the full genomic complement of TE polymorphisms in this way.