Protective effects of flavonoids and extract from Vellozia kolbekii Alves against oxidative stress induced by hydrogen peroxide in yeast

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• 作者：Carmelita Gomes da Silva (1)
  Camilla Dayane F. Carvalho (1)
  Lidilhone Hamerski (1)
  Frederico A. V. Castro (2)
  Ruy José Válka Alves (3)
  Carlos Roland Kaiser (4)
  Elis Cristina Araújo Eleutherio (2)
  Cláudia Moraes de Rezende (1)
  
• 关键词：Vellozia kolbekii (Velloziaceae) ; Antioxidant activity ; Antimutagenic activity ; Flavonoids ; Saccharomyces cerevisiae ; p53 factor
• 刊名：Journal of Natural Medicines
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：66
• 期：2
• 页码：367-372
• 全文大小：266KB
• 参考文献：1. Alves RJV (1992) / Sarcoglottis caudata (Orchidaceae) and / Vellozia kolbekii (Velloziaceae), two new species from Minas Gerais, Brazil. Novon 2:299-01 <a class="external" href="http://dx.doi.org/10.2307/3391481">CrossRefa>
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• 作者单位：Carmelita Gomes da Silva (1)
  Camilla Dayane F. Carvalho (1)
  Lidilhone Hamerski (1)
  Frederico A. V. Castro (2)
  Ruy José Válka Alves (3)
  Carlos Roland Kaiser (4)
  Elis Cristina Araújo Eleutherio (2)
  Cláudia Moraes de Rezende (1)
  
  1. Laboratory of the Analysis of Aromas, Department of Organic Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Athos da Silveira Ramos, 149, University City, 21945-970, Rio de Janeiro, RJ, Brazil
  2. Laboratory of the Investigation of Stress factors (LIFE), Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, 21949-900, Rio de Janeiro, RJ, Brazil
  3. National Museum, Federal University of Rio de Janeiro, 20940-040, Rio de Janeiro, RJ, Brazil
  4. Nuclear Magnetic Resonance Laboratory, Department of Organic Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
  
• ISSN：1861-0293

文摘

Two flavonoids 3,5,7,3-4-pentahydroxy-6-prenylflavonol (1) and 3,5,7,3-4-pentahydroxy-8-methyl-6-prenylflavonol (2) were isolated from the ethyl acetate extract of sheaths of Vellozia kolbekii Alves (Velloziaceae). This is the first time that compound 2 has been described. The crude extract and flavonoids were found to be active as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavengers and were able to the increase tolerance of the eukaryotic microorganism Saccharomyces cerevisiae to oxidative stress generated by H2O2. The protective effect was correlated with a reduction in the oxidation of proteins and lipids. In addition, flavonoids isolated from Velloziaceae showed an inhibitory effect on mutations in p53, which is mutated and nonfunctional in more than 50% of cases of human cancer.