Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (μMi-REM) technique

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• 作者：Dario Carugo ; Jeong Yu Lee ; Anne Pora ; Richard J. Browning…
• 关键词：Microfabrication ; Microfluidic ; Microchannel ; Micromilling ; Pmma ; Replica moulding ; Pdms ; Emulsions ; Microbubbles
• 刊名：Biomedical Microdevices
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：2,175 KB
• 刊物类别：Engineering
• 刊物主题：Biomedical Engineering
  Biophysics and Biomedical Physics
  Nanotechnology
  Engineering Fluid Dynamics
  
• 出版者：Springer Netherlands
• ISSN：1572-8781

文摘

We describe a cost-effective and simple method to fabricate PDMS-based microfluidic devices by combining micromilling with replica moulding technology. It relies on the following steps: (i) microchannels are milled in a block of acrylic; (ii) low-cost epoxy adhesive resin is poured over the milled acrylic block and allowed to cure; (iii) the solidified resin layer is peeled off the acrylic block and used as a mould for transferring the microchannel architecture onto a PDMS layer; finally (iv) the PDMS layer is plasma bonded to a glass surface. With this method, microscale architectures can be fabricated without the need for advanced technological equipment or laborious and time-consuming intermediate procedures. In this manuscript, we describe and validate the microfabrication procedure, and we illustrate its applicability to emulsion and microbubble production.