Losartan and enalapril decrease viral absorption and interleukin 1 beta production by macrophages in an experimental dengue virus infection

详细信息    查看全文

• 作者：Juan Pablo Hernández-Fonseca ; Anyelo Durán ; Nereida Valero…
• 关键词：Dengue virus ; Angiotensin II ; Enalapril ; Losartan ; Macrophages
• 刊名：Archives of Virology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：160
• 期：11
• 页码：2861-2865
• 全文大小：699 KB
• 参考文献：1.Gubler DJ (2002) Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol 10:100–103CrossRef PubMed
  2.Levy A, Valero N, Espina LM, Añez G, Arias J, Mosquera J (2010) Increment of interleukin 6, tumour necrosis factor alpha, nitric oxide, C-reactive protein and apoptosis in dengue. Trans R Soc Trop Med Hyg 104:16–23CrossRef PubMed
  3.Gupta N, Chaturvedi UC (2009) Can helper T-17 cells play a role in dengue haemorrhagic fever? Indian J Med Res 130:5–8PubMed
  4.Pawitan JA (2011) Dengue virus infection: predictors for severe dengue. Acta Med Indones 43:129–135PubMed
  5.Arias J, Valero N, Mosquera J, Montiel M, Reyes E, Larreal Y, Alvarez-Mon M (2014) Increased expression of cytokines, soluble cytokine receptors, soluble apoptosis ligand and apoptosis in dengue. Virology 452–453:42–51. doi:10.​1016/​j.​virol.​2013.​12.​027 CrossRef PubMed
  6.Silva MM, Gil LH, Marques ET Jr, Calzavara-Silva CE (2013) Potential biomarkers for the clinical prognosis of severe dengue. Mem Inst Oswaldo Cruz 108:755–762. doi:10.​1590/​0074-0276108062013012​ PubMedCentral CrossRef PubMed
  7.Benigni A, Cassis P, Remuzzi G (2010) Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med 2:247–257PubMedCentral CrossRef PubMed
  8.Ruiz-Ortega M, Esteban V, Suzuki Y, Ruperez M, Mezzano S, Ardiles L, Justo P, Ortiz A, Egidio J (2003) Renal expression of angiotensin type 2 (AT2) receptors during kidney damage. Kidney Int Suppl 86:S21–S26CrossRef PubMed
  9.Peña C, Hernández-Fonseca JP, Rincón J, Pedreañez A, Viera N, Mosquera J (2013) Proinflammatory role of angiotensin II in mercuric induced nephropathy in rats. J Immunotoxicol 10:125–132CrossRef PubMed
  10.Vargas R, Rincón J, Pedreañez A, Viera N, Hernández-Fonseca JP, Peña C, Mosquera J (2012) Role of Angiotensin II in the brain inflammatory events during experimental diabetes in rats. Brain Res 1453:64–76CrossRef PubMed
  11.Muñoz M, Rincón J, Pedreañez A, Viera N, Hernández-Fonseca JP, Mosquera J (2011) Proinflammatory role of angiotensin II in a rat nephrosis model induced by adriamycin. J Renin Angiotensin Aldosterone Syst 12:404–412CrossRef PubMed
  12.Chang Y, Wei W (2015) Angiotensin II in inflammation, immunity and rheumatoid arthritis. Clin Exp Immunol 179:137–145. doi:10.​1111/​cei.​12467 CrossRef PubMed
  13.Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM (2010) Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther 128:119–128. doi:10.​1016/​j.​pharmthera.​2010.​06.​003 CrossRef PubMed
  14.Yang P, Gu H, Zhao Z, Wang W, Cao B, Lai C, Yang X, Zhang L, Duan Y, Zhang S, Chen W, Zhen W, Cai M, Penninger JM, Jiang C, Wang X (2014) Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep 4:7027–7032. doi:10.​1038/​srep07027 PubMedCentral CrossRef PubMed
  15.Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M (2003) Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426:450–454CrossRef PubMed
  16.Wiehelman K, Braun R, Fitzpatrick J (1988) Investigation of the bicin choninic acid protein assay. Identification of the groups responsible for color formation. Anal Biochem 175:231–237CrossRef
  17.Michl J, Pieczonka MM, Unkeless JC, Silverstein SC (1979) Effects of immobilized immune complexes on Fc- and complement-receptor function in resident and thioglycollate-elicited mouse peritoneal macrophages. J Exp Med 150:607–621CrossRef PubMed
  18.Huang F, Guo J, Zou Z, Liu J, Cao B, Zhang S, Li H, Wang W, Sheng M, Liu S, Pan J, Bao C, Zeng M, Xiao H, Qian G, Hu X, Chen Y, Chen Y, Zhao Y, Liu Q, Zhou H, Zhu J, Gao H, Yang S, Liu X, Zheng S, Yang J, Diao H, Cao H, Wu Y, Zhao M, Tan S, Guo D, Zhao X, Ye Y, Wu W, Xu Y, Penninger JM, Li D, Gao GF, Jiang C, Li L (2014) Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun 5:3595. doi:10.​1038/​ncomms4595 PubMed
  19.Wang P, Chen J, Zheng A, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H (2004) Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun 315:439–444CrossRef PubMed
  20.Simmons G, Zmora P, Gierer S, Heurich A, Pöhlmann S (2013) Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research. Antiviral Res 100:605–614. doi:10.​1016/​j.​antiviral.​2013.​09.​028 PubMedCentral CrossRef PubMed
  21.Wösten-van Asperen RM, Bos AP, Bem RA, Dierdorp BS, Dekker T, van Goor H, Kamilic J, van der Loos CM, van den Berg E, Bruijn M, van Woensel JB, Lutter R (2013) Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome. Pediatr Crit Care Med 14:e438–e441. doi:10.​1097/​PCC.​0b013e3182a55735​ CrossRef PubMed
  22.Ang LT, Tan LY, Chow VT, Sim MK (2012) Des-aspartate-angiotensin I exerts antiviral effects and attenuates ICAM-1 formation in rhinovirus-infected epithelial cells. Eur J Pharmacol 683:310–315CrossRef PubMed
  23.Gulati I, Chaturvedi UC, Mathur A (1982) Depressed macrophage functions in dengue virus infected mice: role of the cytotoxic factor. Br J Exp Pathol 63:194–201PubMedCentral PubMed
  24.Gulati L, Chaturvedi UC, Mathur A (1986) Production of dengue virus-induced macrophage cytotoxin in vivo. Br J Exp Pathol 67:269–277PubMedCentral PubMed
  
• 作者单位：Juan Pablo Hernández-Fonseca (1)
  Anyelo Durán (1)
  Nereida Valero (1)
  Jesús Mosquera (1)
  
  1. Instituto de Investigaciones Clínicas “Dr. Américo Negrette”, Facultad de Medicina, Universidad del Zulia, Apartado Postal 23, Maracaibo, 4001-A, Zulia, Venezuela
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798

文摘

The role of angiotensin II (Ang II) in dengue virus infection remains unknown. The aim of this study was to determine the effect of losartan, an antagonist of the angiotensin II type 1 receptor (AT1 receptor), and enalapril, an inhibitor of angiotensin I-converting enzyme (ACE), on viral antigen expression and IL-1β production in peritoneal macrophages infected with dengue virus type 2. Mice treated with losartan or enalapril and untreated controls were infected intraperitoneally with the virus, and macrophages were analyzed. Infection resulted in increased IL-1β production and a high percentage of cells expressing viral antigen, and this was decreased by treatment with anti-Ang II drugs, suggesting a role for Ang II in dengue virus infection.