Preparation and characterization of superparamagnetic Fe₃O₄/CNTs nanocomposites dual-drug carrier

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• 作者：Xiaojuan Zhang 张小娟 ; Lingyun Hao 郝凌云…
• 关键词：Key wordsFe3O4/CNTs ; nanocomposites ; dual ; drug carrier ; epirubicin ; paclitaxel
• 刊名：Journal of Wuhan University of Technology-Mater. Sci. Ed.
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：32
• 期：1
• 页码：42-46
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Materials Science, general;
• 出版者：Wuhan University of Technology
• ISSN：1993-0437
• 卷排序：32

文摘

Fe₃O₄/carbon nanotubes (Fe₃O₄/CNTs) nanocomposites were prepared by polylol high-temperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene glycol. After surface modification with hexanediamine, folate was covalently linked to the amine group of magnetic Fe₃O₄/CNTs nanocomposites. The products were characterized by Fourier-transform infrared spectroscopy, transmission electron microscopy, and vibrating sample magnetometry. Then Fe₃O₄/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug paclitaxel. The results indicated that the Fe₃O₄/CNTs had a favorable release property for epirubicin and paclitaxel, and thus had potential application in tumor-targeted combination chemotherapy.