Association of oral endothelin receptor antagonists with risks of cardiovascular events and mortality: meta-analysis of randomized controlled trials

详细信息    查看全文

• 作者：Yu Pan ; Chun Hu ; Pei Hua Chen ; Yan Hong Gu…
• 关键词：Oral endothelin receptor antagonist ; Cardiovascular events ; All ; cause mortality ; Major adverse events
• 刊名：European Journal of Clinical Pharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：73
• 期：3
• 页码：267-278
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1041
• 卷排序：73

文摘

BackgroundEndothelin receptor antagonists (ERAs) are widely used in a variety of disorders, including pulmonary artery hypertension, systemic sclerosis, diabetic and kidney diseases, and several tumors. However, reported adverse events, especially increased risks of cardiovascular disease (CVD) morbidity and mortality, have cast doubt on their potential clinical application. Therefore, we conducted this meta-analysis to confirm whether ERAs increased CVD risk and mortality.