Kinetics and thermodynamics of paclitaxel extraction from plant cell culture

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• 作者：Tae Wan Kim ; Jin-Hyun Kim
• 关键词：Paclitaxel ; Extraction ; Kinetics ; Predictive Model ; Thermodynamics
• 刊名：Korean Journal of Chemical Engineering
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：33
• 期：11
• 页码：3175-3183
• 全文大小：487 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Industrial Chemistry and Chemical Engineering
  Catalysis
  Materials Science
  Biotechnology
  
• 出版者：Springer New York
• ISSN：1975-7220
• 卷排序：33

文摘

We investigated the effect of temperature on the efficiency of paclitaxel extraction from biomass. In addition, kinetic and thermodynamic studies of this extraction process were performed. The concentration of extracted paclitaxel increased with increasing extraction temperature and extraction time. When the experimental data were applied to various kinetic models, the hyperbolic model (second-order model) was the most appropriate. The predictive model was developed to predict the concentration of extracted paclitaxel at different temperatures at a given time. The Gibbs free energy change was determined to be negative, while enthalpy change and entropy change were positive. These results indicate that this extraction process is spontaneous, endothermic, and irreversible.