Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries

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• 作者：Madar Talibov ; Monica Guxens ; Eero Pukkala ; Anke Huss…
• 关键词：Extremely low ; frequency magnetic fields ; Electrical shocks ; Acute myeloid leukemia ; Nordic countries ; Case–control study ; Job ; exposure matrix
• 刊名：Cancer Causes & Control
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：26
• 期：8
• 页码：1079-1085
• 全文大小：363 KB
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• 作者单位：Madar Talibov (1)
  Monica Guxens (2) (3) (4) (5)
  Eero Pukkala (1) (6)
  Anke Huss (5)
  Hans Kromhout (5)
  Pauline Slottje (7)
  Jan Ivar Martinsen (8)
  Kristina Kjaerheim (8)
  P?r Sparén (9)
  Elisabete Weiderpass (10) (11) (12) (8) (9)
  Laufey Tryggvadottir (13) (14)
  Sanni Uuksulainen (15)
  Roel Vermeulen (5)
  
  1. School of Health Sciences, University of Tampere, 33014, Tampere, Finland
  2. Centre for Research in Environmental Epidemiology, Barcelona, Spain
  3. Pompeu Fabra University, Barcelona, Spain
  4. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
  5. Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
  6. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland
  7. Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
  8. Cancer Registry of Norway, Oslo, Norway
  9. Department of Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
  10. Department of Community Medicine, Faculty of Health Sciences, University of Troms?, Troms?, Norway
  11. The Arctic University of Norway, Troms?, Norway
  12. Samfundet Folkh?lsan, Helsinki, Finland
  13. Icelandic Cancer Registry, Reykjavik, Iceland
  14. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  15. Finnish Institute of Occupational Health, Helsinki, Finland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Public Health
  Epidemiology
  Hematology
  
• 出版者：Springer Netherlands
• ISSN：1573-7225

文摘

Objective We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA). Methods We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices. We estimated hazard ratios (HRs) and 95?% confidence intervals (95?% CIs) using conditional logistic regression adjusted for concurrent occupational exposures relevant for AML risk (e.g., benzene, ionizing radiation). We conducted sensitivity analyses with different assumptions to assess the robustness of our results. Results Approximately 40?% of the subjects were ever occupationally exposed to low levels and 7?% to high levels of ELF-MF, whereas 18?% were ever at low risk and 15?% at high risk of electrical shocks. We did not observe an association between occupational exposure to neither ELF-MF nor electrical shocks and AML. The HR was 0.88 (95?% CI 0.77-.01) for subjects with high levels of ELF-MF exposure and 0.94 (95?% CI 0.85-.05) for subjects with high risk of electrical shocks as compared to those with background-level exposure. Results remained materially unchanged in sensitivity analyses with different assumptions. Conclusion Our results do not support an association between occupational ELF-MF or electric shock exposure and AML.