Targeting CXCR4 and FAK reverses doxorubicin resistance and suppresses invasion in non-small cell lung carcinoma

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• 作者：Miodrag Dragoj ; Zorica Milosevic ; Jasna Bankovic ; Nikola Tanic…
• 关键词：CXCR4 ; FAK ; DOX ; Resistance ; Invasion ; Non ; small cell lung carcinoma
• 刊名：Cellular Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：1
• 页码：47-62
• 全文大小：
• 刊物主题：Cancer Research; Biomedicine, general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436
• 卷排序：40

文摘

BackgroundCurrent high lung cancer mortality rates are mainly due to the occurrence of metastases and therapeutic resistance. Therefore, simultaneous targeting of these processes may be a valid approach for the treatment of this type of cancer. Here, we assessed relationships between CXC chemokine receptor type 4 (CXCR4) and focal adhesion kinase (FAK) gene expression levels and expression levels of the drug resistance-related genes ABCB1 and ABCC1, and tested the potential of CXCR4 and FAK inhibitors to reverse doxorubicin (DOX) resistance and to decrease the invasive capacity of non-small cell lung carcinoma (NSCLC) cells.